Publications and Manuscripts in preparation

1. Wood, K.V., Lam, Y.A., Seliger, H.H., and McElroy, W.D. (1989) Complementary DNA coding click beetle luciferases can elicit bioluminescence of different colors. Science 244, 700-702.

2. Wood, K.V., Lam, Y.A., McElroy, W.D., and Seliger, H.H. (1989) Bioluminescent click beetles revisited. J. Biolum. Chemilum. 4, 31-39.

3. Wood, K.V., Lam, Y.A., and McElroy, W.D. (1989) Introduction to beetle luciferases and their applications. J. Biolum. Chemilum. 4, 289-301.

4. Lam, Y.A., Xu, W., DeMartino, G.N., and Cohen, R.E. (1997) Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome. Nature 385, 737-740.

5. Lam, Y.A., DeMartino, G.N., Pickart, C.M., and Cohen, R.E. (1997) Substrate specificity of the ubiquitin isopeptidase in the PA700 regulatory complex of 26S proteasomes. J. Biol. Chem. 272, 23712-23721.

6. Lam, Y.A., and Pickart, C.M. (1999) Ubiquitin Pathway. In: Embryonic Encyclopedia of Life Sciences, Nature Publishing Group, London, www.els.net

7. Lam, Y.A., Pickart, C.M., Alban, A., Landon, M., Jamieson, C., Ramage, R., Mayer, R.J., and Layfield, R. (2000) Inhibition of the ubiquitin-proteasome pathway in Alzheimer disease. Proc. Natl. Acad. Sci. USA. 97, 9902-9906.

8. Lam, Y. A., Lawson, T. G., Velayutham, M., Zweier, J. L., Pickart, C. M. (2002) A proteasomal ATPase subunit recognizes the polyubiquitin degradation signal. Nature 416, 763-767.

Lam, Y. A., Huang, J. and Showole, O. (2005) The synthesis and proteasomal degradation of a model substrate Ub5-dihydrofolate reductase. Methods in Enzymology 398, 379-390.

Lam, Y. A., Showole, O., Huang, J., Yao, T., Cohen, R. E., Pickart, C. M. Separation of the energy requirements for substrate unfolding versus translocation in proteolysis by the 26S proteasomes. In preparation.