Publications
&
Peer Reviewed Articles, published
1. Gardenghi S., Ramos P., Marongiu M.F., Melchiori L., Breda L., Guy E., Muirhead K., Rao N., Roy C.N., Andrews N.C., Nemeth E., Follenzi A., An X., Mohandas N., Ginzburg Y., Rachmilewithz E., Giardina P.J., Grady W.R. and Rivella S. “Hepcidin as a therapeutic tool to limit iron overload and improve anemia in beta-thalassemia”. Journal of Clinical Investigation. 2010 Dec 1;120(12):4466-77.
2. Ramos P, Guy E, Gardenghi S, Grady WR, de Sousa M and Rivella S. “Absence of the Hemochromatosis gene HFE in erythroid cells confers protection under condition of stress erythropoiesis and limited iron intake”. Blood. Blood. 2010 Nov 8.
3. Nasimuzzaman M, Khandros E, Wang X, Yi Y, Zhao H, Weiss D, Rivella S, Weiss MJ, and Persons DA. Overexpressed alpha hemoglobin stabilizing protein does not alleviate murine b-thalassemia, American Journal of Hematology, 2010 Oct;85(10):820-2.
4. Vogiatzi MG., Tsay J., Verdelis K., Rivella S., Grady RW., Doty S., Giardina PJ., Boskey AL. “Changes in bone micro-architecture and biomechanical properties in the th3 thalassemia mouse are associated with decreased bone turnover and occur during the period of bone accrual”. Calcified Tissue International. 2010 Jun;86(6):484-94.
5. Salvatori F., Breveglieri G., Zuccato C., Finotti A., Bianchi N., Borgatti M., Feriotto G., Destro F., Canella A., Brognara E., Lampronti I., Breda L., Rivella S. and Gambari R. “Production of adult hemoglobin after G418-mediated correction of the b039 thalassemia mutation of b-globin mRNA produced by b039 thalassemic cells”. American Journal of Hematology. 2009 Nov;84(11):720-8.
6. Chan A.S., Jensen K.K., Skokos D., Doty S., Lederman H.K., Kaplan R.N., Rafi S., Rivella S. & Lyden D. “Id1 Represses Osteoclast-Dependent Transcription and Affects Bone Formation and Hematopoiesis”. Rivella and Lyden corresponding authors. PLoS ONE; 2009 Nov 24;4(11):e7955
7. Biagioli M., Pinto M., Cesselli D., Zaninello M., Lazarevic D., Roncaglia P., Simone R., Vlachouli C., C., Bertin N., Beltrami A., Kobayashi K., Gallo V., Santoro C., Ferrer I., Rivella S., Beltrami C.A., Carninci P., Raviola E. and Gustincich S. “An old protein in unexpected places: alpha- and beta- globin expression in mesencephalic dopaminergic neurons and glial cells”. PNAS. 2009 Sep 8;106(36):15454-9
8. Salvatori F, Cantale V, Breveglieri G, Zuccato C, Finotti A, Bianchi N, Borgatti M, Feriotto G, Destro F, Canella A, Breda L, Rivella S., Gambari R. “Development of K562 cell clones expressing beta-globin mRNA carrying the beta039 thalassemia mutation for the screening of correctors of stop codon mutations.” Biotechnology and Applied Biochemistry; 2009 Jul 9;54(1):41-52.
9. Libani IV, Guy E, Melchiori L, Schiro R, Ramos P, Breda L, Scholzen T, Chadburn A, Liu Y, Kernbach M, Baron-Luehr B, Porotto M, de Sousa M, Rachmilewitz E, Hood JD, Domenica Cappellini M, Giardina PJ, Grady RW, Gerdes J and Rivella S. “Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia”. Blood, 2008 Aug 1;112(3):875-85.
10. Pinto JP, Ramos P, de Almeida SF, Oliveira S, Breda L, Michalak M, Porto G, Rivella S and de Sousa M. “Protective role of calreticulin in HFE Hemochromatosis”, Free Radical Biology & Medicine; 2008 Jan 1; 44(1):99-108.
11. Gardenghi S, Marongiu MF, Ramos P, Guy E, Breda L, Chadburn A, Liu Y, Amariglio N, Rechavi G, Rachmilewitz EA, Breuer W, Cabantchik ZI, Wrighting DM, Andrews NC, de Sousa M, Giardina PJ, Grady RW and Rivella S. "Ineffective erythropoiesis in Beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin". Blood; 2007 Jun 1; 109(11):5027-35.
12. Weizer-Stern O, Adamsky K, Amariglio N, Levin C, Koren A, Breuer W, Rachmilewitz E, Breda L, Rivella S, Ioav Cabantchik Z, Rechavi G. “Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera”. British Journal of Haematology; 2006 Oct; 135(1):129-38.
13. Weizer-Stern O, Adamsky K, Amariglio N, Rachmilewitz E, Breda L, Rivella S. and Rechavi G. “mRNA expression of iron regulatory genes in beta-thalassemia intermedia and beta-thalassemia major mouse models”. American Journal of Hematology; 2006 Jul;81(7):479-83
14. Adamsky AK, Weizer O, Amariglio N, Breda L, Harmelin A, Rivella S, Rachmilewitz E, Rechavi G. “Decreased hepcidin mRNA expression in thalassemic mice”. British Journal of Haematology; 2004 Jan;124(1):123-4
15. Rivella S, May C, Chadburn A, Riviere I, Sadelain M. ”A novel murine model of Cooley anemia and its rescue by lentiviral mediated human beta-globin gene transfer”. Blood; 2003 Apr 15; 101(8):2932-9.
16. May C, Rivella S, Chadburn A, Sadelain M. “Successful treatment of beta-thalassemia intermedia by transfer of the human βeta-globin gene”. Blood; 2002 Mar 15; 99(6):1902-8.
17. May C, Rivella S, Callegari J, Heller G, Gaensler KM, Luzzatto L, Sadelain M. "Therapeutic haemoglobin synthesis in beta-thalassaemic mice expressing lentivirus-encoded human beta-globin". Nature; 2000 Jul 6; 406(6791):82-6.
18. Rivella S, Callegari J, May C, Cui Wen T. and Sadelain M. “The cHS4 Insulator Increases the Probability of Retroviral Expression At Random Chromosomal Integration Sites”. Journal of Virology; 2000 May; 74(10):4679-87.
19. Rivella S, Palermo B, Pelizon C, Sala C, Arrigo G and Toniolo D. “Selection and mapping of replication origins from a 500 kb region of the human X chromosome and their relation to gene expression”. Genomics; 1999 Nov 15; 62(1): 11-20.
20. Mancini M, Sala C, Rivella S, and Toniolo D. “Selection and fine mapping of chromosome specific cDNAs: application to human chromosome”. Genomics; 1996 Dec 1; 38(2):149-54.
21. Rivella S, Bione S, Maestrini E, Tamanini F, Mancini M, Tribioli C and Toniolo D. "A comparative transcriptional map of a region of 200 kb on the human and mouse X chromosome between the G6PD and the FLN genes". Genomics; 1995 Aug 10; 28(3): 377-82
22. Bione S, Maestrini E, Rivella S, Mancini M, Regis S, Romeo G and Toniolo D. "Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy". Nature Genetics; 1994 Dec; 8(4):323-7.
23. Bione S, Tamanini F, Maestrini E, Tribioli C, Poustka A, Torri G, Rivella S and Toniolo D. "Transcriptional organization of a 450 kb region of the human X chromosome, in Xq28". PNAS; USA; 1993 Dec 1; 90(23):10977-81.
24. Rousseau F, Vincent A, Rivella S, Heitz D, Tribioli C, Maestrini E, Warren ST, Suthers GK, Goodfellow P, Mandel JL, Toniolo D and Oberlé I. "Four chromosomal breakpoints and four new probes mark out a 10 cM region encompassing the FRAXA locus". American Journal of Human Genetics; 1991 Jan; 48(1):108-16.
25. Maestrini E, Rivella S, Tribioli C, Purtilo D, Rocchi M, Archidiacono N and Toniolo D. "Probes for CpG islands of the human X chromosome are clustered in Xq24 and Xq28". Genomics; 1990 Dec; 8(4):664-70.
26. Gariboldi M, Maestrini E, Canzian F, Manenti G, De Gregorio L, Rivella S, Chatterjee A, Herman GH, Archidiacono N, Antonacci R, Pierotti M, Dragani TA and Toniolo D. "Comparative mapping of the Actin Binding Protein 280 Genes in Human and Mouse". Genomics; 1994 May 15; 21(2):428-30.
27. Tribioli C, Mancini M., Plassart E., Bione S., Rivella S., Sala C., Torri G. and Toniolo D. "Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD N-acetyl transferase of Saccharomices cerevisiae". Human Molecular Genetics; 1994 Jul; 3(7):1061-7
28. Maestrini E, Patrosso C, Mancini M, Rivella S, Rocchi M, Repetto M, Villa A, Frattini A, Zoppè M, Vezzoni P and Toniolo D. "Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7". Human Molecular Genetics; 1993 Jun; 2(6):761-6
29. Tribioli C, Tamanini F, Patrosso C, Milanesi L, Villa A, Pergolizzi R, Maestrini E, Rivella S, Bione S, Mancini M, Vezzoni P and Toniolo D. "Methylation and sequence analysis around EagI sites: identification of 28 new CpG islands in Xq24-Xq28". Nucleic Acids Research; 1992 Feb 25; 20(4):727-33
30. Maestrini E, Rivella S, Tribioli C, Rocchi M, Camerino G, Santachiara-Benerecetti S, Parolini O, Notarangelo LD and Toniolo D. "Identification of novel RFLPs in the vicinity of CpG islands in Xq28: application to the analysis of the pattern of X chromosome inactivation". American Journal of Human Genetics; 1992 Jan; 50(1):156-63.
31. Manoni M, Tribioli C, Lazzari B, DeBellis G, Patrosso C, Pergolizzi R, Pellegrini M, Maestrini E, Rivella S, Vezzoni P and Toniolo D. "The nucleotide sequence of a CpG island demonstrates the presence of the first exon of the gene encoding the human& lysosomal membrane protein LAMP2, and assigns the gene to Xq24". Genomics; 1991 Mar; 9(3):551-4
Books, Book Chapters and Reviews, published
1. Gardenghi S., Grady W.R., and Rivella S. “Anemia, ineffective erythropoiesis and hepcidin: interacting factors in abnormal iron metabolism leading to iron overload in beta thalassemia”. Hematology/Oncology Clinics of North America on Thalassemia, Elsevier 2010 Dec;24(6):1089-107.
2. Breda L, Kleinert DA, Casu C, Casula L, Cartegni L, Fibach E, Mancini I, Giardina PJ, Gambari R and Stefano Rivella S. “A Preclinical Approach for Gene Therapy of β-Thalassemia”. Annals of the New York Academy of Sciences: Cooley’s Anemia Annals. 2010 Aug;1202:134-40.
3. Gardenghi S, Ramos P, Follenzi A, Rao N, Rachmilewitz EA, Giardina PJ, Grady RW and Rivella S. & “Hepcidin and Hfe in Iron Overload in ß-Thalassemia”. Annals of the New York Academy of Sciences: Cooley’s Anemia Annals. 2010 Aug;1202:221-5.
4. Ramos P, Melchiori L, Gardenghi S, van Rooijen N, Grady RW, Ginzburg Y and Rivella S. “Iron metabolism and ineffective erythropoiesis in ß-thalassemia mouse models”. Annals of the New York Academy of Sciences: Cooley’s Anemia Annals. 2010 Aug;1202:24-30.
5. Rivella S, Nemeth E, Miller JL. Crosstalk between Erythropoiesis and Iron Metabolism. Advances in Hematology. 2010;2010. pii: 317095. Epub 2010 Aug 24. Rivella corresponding author.
6. Rivella S. Guest Editor on a special issue on “Iron metabolism and erythropoiesis” and Invited review: Melchiori L., Gardenghi S. and Rivella S. “β-thalassemia: HiJAKing ineffective erythropoiesis and iron overload”. Adv Hematol. 2010;2010:938640.
7. Breda L. and Rivella S. “Gene Therapy& in Thalassemia and Hemoglobinopathies”. Invited review: Mediterranean Journal of Hematology and Infectious Diseases. Epub 2009 Nov
8. Rivella S. and Rachmilewitz E “Alternative therapies for thalassemia”. Expert Review of Hematology. 2009 Dec 1;2(6):685.
9. Rivella S. “Ineffective erythropoiesis and thalassemias”. Current Opinion in Hematology 2009 May;16(3):187-94.
10. G. Rechavi and S. Rivella “Regulation of Iron Absorption in Hemoglobinopathies“. Current Molecular Medicine; 2008 Nov; 8(7):646-62.
11. Breveglieri G, Salvatori F, Finotti A, Bertuzzi I, Destro F, Falzoni S, Bianchi N, Borgatti M, Zuccato C, Feriotto G, Breda L, Rivella S and Gambari R. “Cellular biosensors for the identification of fetal hemoglobin inducers”. Minerva Biotecnologica 2007; vol. 19-4: 123-32
12. Sadelain M, Boulad F, Galanello R, Giardina P, Locatelli F, Maggio A, Rivella S, Riviere I and Tisdale J. "Therapeutic options for patients with severe beta-thalassemia: the need for globin gene therapy". Human Gene Therapy; 2007 Jan; 18(1):1-9.
13. Breda L, Gardenghi S, Guy E, Rachmilewitz EA, Weizer-Stern O, Adamsky K, Amariglio N, Rechavi G, Giardina PJ, Grady RW and Rivella S. “Exploring the role of hepcidin, an antimicrobial and iron regulatory peptide, in increased iron absorption in beta-thalassemia”. Annals of the New York Academy of Sciences: Cooley’s Anemia Annals; 2005; 1054:417-22.
14. Sadelain M, Lisowski L, Samakoglu S, Rivella S, May C and Riviere I. “Progress toward the genetic treatment of the beta-thalassemias”. Annals of the New York Academy of Sciences: Cooley’s Anemia Annals; 2005; 1054:78-91.
15. Rachmilewitz E, Breda L, Weizer-Stern Orly, Adamsky Konstantin, Amarigleo N, Rechavi G, Rivella S and Cabantchik I. “The role of iron in inducing oxidative stress in thalassemia: can it be prevented by inhibition of absorption and by antioxidants?”. Annals of the New York Academy of Sciences: Cooley’s Anemia Annals; 2005; 1054:118-23.
16. Sadelain M, Rivella S, Lisowski L, Samakoglu S and Riviere I.& “Globin gene transfer for treatment of the beta-thalassemias and sickle cell disease”. Best Practice & Research Clinical Haematology; 2004 Sep; 17(3):517-34.
17. Breda L and Rivella S. “Development of new mouse models to study globin gene regulation”. Minerva Biotecnologica; Vol 5 (2), June 2003.
18. Rivella S, Lisowski L and Sadelain M. “Globin gene transfer: a paradigm for transgene regulation and improved vector safety”, Gene Therapy and Regulation; 2003; 2: 149-75
19. Rivella S and Sadelain M. “Therapeutic globin gene delivery using lentiviral vectors”. Current Opinion in Molecular Therapy;. 2002 Oct; 4(5):505-14.
20. Sadelain M, May C, Rivella S and Glade Bender J.& “Basic principles of gene transfer in hematopoietic stem cells”. J.R. Bertino (Ed): Marrow Protection; Progress in Experimental Tumor Research; Basel, Karger AG, 1999; 36:1-19.
21. Rivella S, Tribioli C, Maestrini E, Tamanini F,Bione S, Medolfi ME, Frattini A, Vezzoni P, and Toniolo D. "CpG island: markers to identify human genes". Minerva Biotecnologica; 1999; 3, 2-7.
22. Rivella S and Sadelain M. “Genetic treatment of severe hemoglobinopathies: the combat against transgene variegation and transgene silencing”. Seminars in Hematology; 1998 Apr; 35(2):112-25.
23. Tribioli C, Maestrini E;, Bione S, Tamanini F, Mancini M, Sala C, Torri G, Rivella S and Toniolo D. "Identification of genes and construction of a transcriptional map in Xq28". Identification of Transcribed Sequences-Plenum Press; 1994; New York.
