Publications
Tan MP, Sequeira P, Lin WW, Phong WY, Cliff P, Ng SH, Lee BH, Camacho L, Schnappinger D, Ehrt S, Dick T, Pethe K, Alonso S (2010). Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses. PlosOne 5(10):e13356.
de Carvalho LPS, Fischer SM, Marrero J, Nathan C, Ehrt S, Rhee KY (2010). Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates. Chemistry & Biology 17(10):1122-31
Seimon TA, Kim M, Blumenthal A, Koo J, Ehrt S, Wainwright H, Bekker L, Kaplan G, Nathan C, Tabas I, Russell DG (2010). Induction of ER Stress in Macrophages of Tuberculosis Granulomas. Plos One 5(9): e12772
Biswas T, Small J, Vandal O, Odaira T, Deng H, Ehrt S, Tsodikov O. (2010) Structural insight into serine protease Rv3671c that protects M. tuberculosis from oxidative and acidic stress. Structure, 18,1353-63.
Gandotra S, Lebron M, Ehrt S. (2010) The Mycobacterium tuberculosis Proteasome Active Site Threonine Is Essential for Persistence Yet Dispensable for Replication and Resistance to Nitric Oxide. Plos Pathogens,6(8)pii:e1001040.
Marrero J, Rhee KY, Schnappinger D, Pethe K, Ehrt S. (2010) Gluconeogenic carbon flow of tricarboxylic acid cycle intermediates is critical for Mycobacterium tuberculosis to establish and maintain infection. PNAS 107 (21) 9819-24.
Barry CE, Boshoff H, Dartois V, Dick T, Ehrt S, Flynn E, Schnappinger D, Wilkinson RJ, Young D. (2009) The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nature Rev Microbiology, 7(12):845-55.
Vandal, OH, Nathan, C, Ehrt S. (2009) Acid resistance in Mycobacterium tuberculosis. J. Bacteriology, 191(15): 4714-21
Klotzsche M, Ehrt S, Schnappinger D. (2009) Improved tetracycline repressors for gene silencing in mycobacteria. Nucleic Acids Research, Nucleic Acids Res. 37(6):1778-88
Blumenthal, A, Kobayashi T, Pierini, LM, Banaiee N, Ernst JD, Miyake K, and Ehrt S. (2009) RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins. Cell Host & Microbe, 5(1):35-46
Vandal OH, Roberts JA, Odaira T, Schnappinger D, Nathan CF, Ehrt S. (2009) Acid-susceptible mutants of Mycobacterium tuberculosis share hypersusceptibility to cell wall and oxidative stress and to the host environment. J. Bacteriol. 191(2): 625-31
Vandal O, Pierini LM, Schnappinger D, Nathan CF, Ehrt S. (2008) A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis. Nature Medicine, 14(8):849-54
Boshoff HIM, Xu X, Tahlan K, Dowd CS, Pethe K, Camacho LR, Park TH, Yun CS, Schnappinger D, Ehrt S, Williams KJ, and Barry CE. (2008) Biosynthesis and recycling of nicotinamide cofactors in Mycobacterium tuberculosis: an essential role for NAD in non-replicating bacilli. J. Biol. Chem, 283, 19329-41
Bryk R, Gold B, Venugopal A, Singh J, Samy R, Pupek K, Cao H, Popescu C, Gurney M, Hotha S, Cherian J, Rhee K, Ly L, Converse PJ, Ehrt S, Vandal O, Jiang X, Schneider J, Lin G, Nathan C. (2008). Selective killing of nonreplicating mycobacteria. Cell Host Microbe. 3, 137-145.
Gandotra, S., Schnappinger, D., Monteleone, M., Hillen, W., and Ehrt, S. (2007). In vivo gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nature Medicine 13, 1515-1520.
Gandotra, S., Jang, S., Murray, P.J., Salgame, P., and S. Ehrt. (2007). Nucleotide-Binding Oligomerization Domain Protein 2-deficient mice control infection with Mycobacterium tuberculosis. Infect. Immun. 75, 5127-34
Guo, V., Monteleone, M., Klotzsche, M., Kamionka, A., Hillen, W., Braunstein, M., Ehrt, S., Schnappinger, D. (2007). Silencing essential protein secretion in Mycobacterium smegmatis using tetracycline repressors. J. Bacteriol.189:4614-23&
Ehrt, S., Schnappinger, D. (2006). Controlling gene expression in mycobacteria. Future Microbiology, 1, 177-184
Schnappinger, D., Schoolnik, GK., Ehrt, S. (2006). Expression profiling of host pathogen interactions: how M. tuberculosis and the macrophage adapt to one another. Microbes & Infection, 8,1132-40.
Shi, S., Ehrt, S. (2005). Dihydrolipoamide acyltransferase (DlaT) is critical for Mycobacterium tuberculosis pathogenesis. Infect. Immun. 74, 56-63.
Shi, S., Blumenthal, A., Hickey, C.M., , Gandotra, S., Levy, D. and Ehrt, S. (2005). Viable Mycobacterium tuberculosis induces expression of immunologically important genes in macrophages through a pathway independent of both TLR2 and TLR4 but dependent on IFNab-receptor and STAT1. J. Immunol.175, 3318-3328.
Ding, Yu, H., Yang, J., Shuangping, S. and Ehrt, S. (2005). Induction of macrophage-derived SLPI by Mycobacterium tuberculosis depends on TLR2 but not MyD88. Immunology. 116, 381-389.
Morris, RP., Nguyen, L., Gatfield, J., Visconti, K., Nguyen, K., Schnappinger, D., Ehrt, S., Liu, Y., Heifets, L., Pieters, J., Schoolnik, G., Thompson, C. (2005). Ancestral antibiotic resistance in Mycobacterium tuberculosis. PNAS. 102, 12200-5.
Ehrt, S., Guo, X.V., Hickey, C.M., Ryou, M., Monteleone, M., Riley, L.W., and Schnappinger, D. (2005). Controlling gene expression in mycobacteria with anhydrotetracycline and Tet repressor. Nucleic Acids Res. 33:e21.
Darwin, K.H., Ehrt, S. Gutierrez-Ramos, J., Weich, N. and Nathan, C. (2003). The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide. Science. 302,1963-1966.
Shi, S., Nathan, C., Schnappinger, D., Drenkow, J., Fuortes, M., Block, E., Ding, A., Gingeras, T.R., Schoolnik, G., Akira, S., Takeda, K., and Ehrt, S (2003). MyD88 primes macrophages for full-scale activation by interferon-g yet mediates few responses to Mycobacterium tuberculosis. J. Exp. Med. 198, 987-997.
Schnappinger, D., Ehrt, S., Voskuil, M.I., Liu, Y., Mangan, J.A., Monahan, I.M., Dolganov, G., Efron, B., Butcher, P.D., Nathan, C., and Schoolnik, G.K. (2003). Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment. J. Exp. Med. 198, 693-704.
Ehrt, S., Schnappinger, D., Bekiranov, S., Drenkow, J., Shi, S., Gingeras, T. R., Gaasterland, T., Schoolnik, G. and Nathan, C. (2001). Reprogramming of the macrophage transcriptome in response to interferon-g and Mycobacterium tuberculosis: Signaling roles of nitric oxide synthase-2 and phagocyte oxidase. J. Exp. Med. 194, 1123-1139
