Select Publications:

Silver, R.B., C. Mackins, N.C.E. Smith, I. Koritchneva, T.W. Lovenberg, K. Lefkowitz, and R. Levi. (2001).Coupling of histamine H3-receptors to neuronal Na+/H+ exchange: a novel protective mechanism in myocardial ischemia. Proc. Nat. Acad. Sci. (USA) 98: 2855-2859.

Silver, R.B., K.S. Poonwasi, N. Seyedi, S. Wilson, T.W. Lovenberg, and R. Levi (2002). Decreased intracellular calcium mediates the histamine H3-receptor induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings. Proc. Nat. Acad. Sci. (USA) 99: 501- 506.

Stern, J.M., J. Chen, R.B. Silver, D. Poppas, D. Vaughan, and D. Felsen. (2004) Effect of unilateral urinary obstruction on dopamine 1a receptor expression reveals a link between dopamine, transforming growth factor, and nitric oxide. Am. J. Physiol. 286:F509-515.

Reid, A.C., C.J. Mackins, N. Seyedi,, R. Levi, and R.B. Silver. (2004). Coupling of angiotensin II AT1 receptors to neuronal NHE activity and carrier-mediated norepinephrine release in myocardial ischemia. Am J. Physiol. 286:H1448-H1454.

Silver, R.B., Reid, A.C., Mackins, C., Askwith, T., Schaefer, U., Herzlinger, D., and Levi, R. (2004) Mast cells: A unique source of renin. Proc. Natl. Ac. Sci. (USA) 101: 13607-13612.

Seyedi, N., Mackins, C.J., Machida, T., Reid, A.C., Silver, R.B., and Levi, R. (2005) Histamine H3-receptor-induced attenuation of norepinephrine exocytosis: a decreased PKA activity mediates a reduction in intracellular calcium. J. Pharmacol. Exp. Ther. 312: 272-280.

Mackins, C.J., Kano, S. , Seyedi, N., Schaefer, U., Reid, A.C., Machida, T., Silver, R.B., Levi, R. (2006). Cardiac mast-cell-derived renin promotes local angiotensin formation, norepinephrine release and arrhythmias in ischemia/reperfusion. J. Clin. Invest.116: 1063-70.

Levi,R., Seyedi, N., Schaefer, U., Estephan, R., Mackins, C.J., Tyler, E., and Silver, R.B. (2007). Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a Novel MAPK-PLA2-COX-PGE2-EP3R pathway. Biochem. Pharmacol. 15: 73: 1146-1156.

Kano, S., Tyler, E., Salazar-Rodriguez, M., Estephan, R., Mackins, C.J., Reid, A.C., Silver, R.B., and R. Levi. (2007) Immediate hypersensitivity elicits renin release from cardiac mast cells. Int. Arch. Allergy Immunol. 146: 71-75.

Veerappan, A., Reid, A.C., Thadani-Mulero, M., Salazar-Rodriguez,M., Levi, R. and R.B. Silver (2008). Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction. Proc. Natl. Acad. Sci (USA) 105: 1315-20.