Jia F, Chandra D, Homanics GE, Harrison NL. Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus. J Pharmacol Exp Ther. 2008 Aug;326(2):475-82. Epub 2008 May 13.
PMID: 18477766

Keramidas A, Harrison NL. Agonist-dependent single channel current and gating in alpha4beta2delta and alpha1beta2gamma2S GABAA receptors. J Gen Physiol. 2008 Feb;131(2):163-81.
PMID: 18227274

Trudell JR, Yue ME, Bertaccini EJ, Jenkins A, Harrison NL. Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit. J Chem Inf Model. 2008 Feb;48(2):344-9. Epub 2008 Jan 16.
PMID: 18197653

Jia F, Yue M, Chandra D, Keramidas A, Goldstein PA, Homanics GE, Harrison NL. Taurine is a potent activator of extrasynaptic GABA(A) receptors in the thalamus. J Neurosci. 2008 Jan 2;28(1):106-15.
PMID: 18171928

Jia F, Yue M, Chandra D, Homanics GE, Goldstein PA, Harrison NL. Isoflurane is a potent modulator of extrasynaptic GABA(A) receptors in the thalamus. J Pharmacol Exp Ther. 2008 Mar;324(3):1127-35. Epub 2007 Dec 19.
PMID: 18094320

Chandra D, Werner DF, Liang J, Suryanarayanan A, Harrison NL, Spigelman I, Olsen RW, Homanics GE. Normal acute behavioral responses to moderate/high dose ethanol in GABAA receptor alpha 4 subunit knockout mice. Alcohol Clin Exp Res. 2008 Jan;32(1):10-8. Epub 2007 Dec 12.
PMID: 18076749

Pignataro L, Miller AN, Ma L, Midha S, Protiva P, Herrera DG, Harrison NL. Alcohol regulates gene expression in neurons via activation of heat shock factor 1. J Neurosci. 2007 Nov 21;27(47):12957-66.
PMID: 18032669

Harrison NL. Mechanisms of sleep induction by GABA(A) receptor agonists. J Clin Psychiatry. 2007;68 Suppl 5:6-12. Review.
PMID: 17539703

Jia F, Pignataro L, Harrison NL. GABAA receptors in the thalamus: alpha4 subunit expression and alcohol sensitivity. Alcohol. 2007 May;41(3):177-85. Epub 2007 May 23. Review.
PMID: 17521848

Sonner JM, Werner DF, Elsen FP, Xing Y, Liao M, Harris RA, Harrison NL, Fanselow MS, Eger EI 2nd, Homanics GE. Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isoflurane. Anesthesiology. 2007 Jan;106(1):107-13.
PMID: 17197852

Chandra D, Jia F, Liang J, Peng Z, Suryanarayanan A, Werner DF, Spigelman I, Houser CR, Olsen RW, Harrison NL, Homanics GE. GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15230-5. Epub 2006 Sep 27.
PMID: 17005728

Cammidge AN, Goddard VH, Gopee H, Harrison NL, Hughes DL, Schubert CJ, Sutton BM, Watts GL, Whitehead AJ. Aryl trihydroxyborates: easily isolated discrete species convenient for direct application in coupling reactions. Org Lett. 2006 Aug 31;8(18):4071-4.
PMID: 16928076

Borghese CM, Werner DF, Topf N, Baron NV, Henderson LA, Boehm SL 2nd, Blednov YA, Saad A, Dai S, Pearce RA, Harris RA, Homanics GE, Harrison NL. An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice. J Pharmacol Exp Ther. 2006 Oct;319(1):208-18. Epub 2006 Jun 28.
PMID: 16807363

Werner DF, Blednov YA, Ariwodola OJ, Silberman Y, Logan E, Berry RB, Borghese CM, Matthews DB, Weiner JL, Harrison NL, Harris RA, Homanics GE. Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol. J Pharmacol Exp Ther. 2006 Oct;319(1):219-27. Epub 2006 Jun 19.
PMID: 16785315

Keramidas A, Kash TL, Harrison NL. The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor. J Physiol. 2006 Aug 15;575(Pt 1):11-22. Epub 2006 Jun 8.
PMID: 16763005

Elsen FP, Liljelund P, Werner DF, Olsen RW, Homanics GE, Harrison NL. GABA(A)-R alpha1 subunit knockin mutation leads to abnormal EEG and anesthetic-induced seizure-like activity in mice. Brain Res. 2006 Mar 17;1078(1):60-70. Epub 2006 Feb 21.
PMID: 16490182

Ying SW, Abbas SY, Harrison NL, Goldstein PA. Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons. Eur J Neurosci. 2006 Jan;23(2):465-80. Erratum in: Eur J Neurosci. 2006 Mar;23(5):1403.
PMID: 16420453

Sonner JM, Vissel B, Royle G, Maurer A, Sailer A, Gong D, Baron NV, Harrison NL, Heinemann S, Fanselow M, and Eger EI. (2005) The effect of three inhaled anesthetics in mice harboring mutations in the GluR6 (kainate) receptor gene. Anesthesia and Analgesia, 101: 143-148.

Jia F, Pignataro L, Schofield CM, Yue M, Harrison NL, Goldstein PA. (2005) An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. J Neurophysiol. Dec;94(6):4491-501.

Hemmings HC Jr, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. (2005) Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci. Oct;26(10):503-10. Review.

Cacheaux LP, Topf N, Tibbs GR, Schaefer UR, Levi R, Harrison NL, Abbott GW, Goldstein PA. (2005) Impairment of hyperpolarization-activated, cyclic nucleotide-gated channel function by the intravenous general anesthetic propofol. J Pharmacol Exp Ther. Nov;315(2):517-25.

Hall AC, Stevens RJ, Betts BA, Yeung WY, Kelley JC, Harrison NL. (2005) Subunit-dependent block by isoflurane of wild-type and mutant alpha(1)S270H GABA(A) receptor currents in Xenopus oocytes. Neurosci Lett. 382(3):332-7.

Schofield CM, Harrison NL. (2005) Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit. Brain Res. 1032(1-2):30-5.

Homanics GE, Elsen FP, Ying SW, Jenkins A, Ferguson C, Sloat B, Yuditskaya S, Goldstein PA, Kralic JE, Morrow AL, Harrison NL. (2005) A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouse. Genes Brain Behav. 4(1):10-9.

Kash TL, Trudell JR, Harrison NL. (2004) Structural elements involved in activation of the gamma-aminobutyric acid type A (GABAA) receptor. Biochem Soc Trans. 32(Pt 3):540-6.

Hall AC, Rowan KC, Stevens RJ, Kelley JC, Harrison NL. (2004) The effects of isoflurane on desensitized wild-type and alpha 1(S270H) gamma-aminobutyric acid type A receptors. Anesth Analg. 98(5):1297-304.

Castaldo P, Stefanoni P, Miceli F, Coppola G, Del Giudice EM, Bellini G, Pascotto A, Trudell JR, Harrison NL, Annunziato L, Taglialatela M. (2004) A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists. J Biol Chem. 279(24):25598-604.

Kash TL, Dizon MJ, Trudell JR, Harrison NL. (2004) Charged residues in the beta2 subunit involved in GABAA receptor activation. J Biol Chem. 279(6):4887-93.

Kash TL, Jenkins A, Kelley JC, Trudell JR, Harrison NL. (2003) Coupling of agonist binding to channel gating in the GABAA receptor. Nature 421:272-275.

Other Publications