Publications
Weiguo, Soll, Chavadi, Zhang, Warren, and Quadri (2009). Cooperation between a Coenzyme A-Independent Stand-Alone Initiation Module and an Iterative Type I Polyketide Synthase during Synthesis of Mycobacterial Phenolic Glycolipids. J. Am. Chem. Soc. 131:16744-16750.
Xu, Tertilt, Krause, Quadri, Crystal, and Worgall (2009). Influence of the cystic fibrosis transmembrane conductance regulator on expression of lipid metabolism-related genes in dendritic cells. Respir. Res. 10:26. [Flagged as "Highly Accessed" by Respir. Res.]
Ferreras, Stirrett, Lu, Ryu, Soll, Tan, and Quadri (2008). Mycobacterial phenolic glycolipid virulence factor biosynthesis: mechanism and small-molecule inhibition of polyketide chain initiation. Chem. Biol. 15:51-61. [Highlighted in Start-Up Magazine, January issue, 2008]
Stirrett, Ferreras, Rossi, Moy, Fonseca, and Quadri (2008). A multicopy suppressor screening approach as a means to identify antibiotic resistance determinant candidates in Yersinia pestis. BMC Microbiol. 8:122. [Flagged as "Highly Accessed" by BMC Microbiol.]
Stirrett, Ferreras, Jayaprakash, Sinha, Ren, and Quadri (2008). Small‑molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis. Bioorg. Med. Chem. Lett. 18:2662-2668.
Quadri (2008). Iron uptake in mycobacteria. In The Mycobacterial Cell Envelope.Eds: Daffe & Reyrat. ASM Press, Washington, DC. pp. 167-184.
Crick, Quadri, and Brennan (2008). Biochemistry of the Cell Envelope of Mycobacterium tuberculosis. In Handbook of Tuberculosis: Molecular Biology and Biochemistry. Eds: Kaufman & Rubin. WILEY-VCH Verlag GmbH & Co. KgaA, Weinheim. pp 1-20.
Quadri (2008). Iron uptake by Mycobacterium tuberculosis. In Handbook of Tuberculosis: Molecular Biology and Biochemistry. Eds: Kaufman & Rubin. WILEY-VCH Verlag GmbH & Co. KgaA, Weinheim. pp 91-110.
Cisar, Ferreras, Soni, Quadri, and Tan (2007). Exploiting ligand conformation in the selective inhibition of nonribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules. J. Am. Chem. Soc. 129:7752-7753. [Highlighted in Faculty of 1000 by Ross Weatherman and by Dennis Hall: http://www.f1000biology.com/article/id/1087363]
Quadri (2007). Strategic paradigm shifts in the antimicrobial drug discovery process of the 21st century. Infect. Disord. Drug Targets. 7:230-237.
Rohde and Quadri (2006). Functional characterization of a three-component regulatory system involved in quorum sensing-based regulation of peptide antibiotic production in Carnobacterium maltaromaticum. BMC Microbiol. 6:93.
Ferreras, Ryu, Di Lello, Tan, and Quadri (2005). Small‑molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nat. Chem. Biol. 1:29-32. [Highlighted in the Research Highlights section of Nature, 2005, 435:389 and in the News of the Week section of Chemical. & Eng. News, 2005, 83:13.]
Onwueme, Vos, Zurita, Ferreras, and Quadri (2005). The dimycocerosate ester polyketide virulence factors of mycobacteria. Prog. Lipid Res. 44:259-302.
Worgall, Heguy, Luettich, O?Connor, Harvey, Quadri, and Crystal (2005). Similarity of patterns in gene expression of human alveolar macrophages evoked by Pseudomonas aeruginosa and Burkholderia cepacia. Infect. Immun. 73:5262-5268.
Onwueme, Vos, Zurita, Soll, and Quadri (2005). Identification of phthiodiolone ketoreductase, an enzyme required for production of mycobacterial diacyl phthiocerol virulence factors. J. Bacteriol. 187:4760-4766.
Palma, Zurita, Ferreras, Worgall, Larone, Shi, Campagne, and Quadri (2005). Pseudomonas aeruginosa SoxR does not conform to the archetypal paradigm for SoxR-dependent regulation of the bacterial oxidative stress adaptive response. Infect. Immun. 73:2958-2966.
Quadri and Ratledge (2005). Iron metabolism in the tubercle bacillus and other mycobacteria. In Tuberculosis and the Tubercle Bacillus. Eds: McMurray, Eisenach, Gicquel and Jacobs, Jr. ASM Press, Washington, DC. p. 341-357.
Onwueme, Ferreras, Buglino, Lima, and Quadri (2004). Mycobacterial polyketide‑associated proteins are acyltransferases: Proof of principle with Mycobacterium tuberculosis PapA5. Proc. Natl. Acad. Sci. U.S.A. 101:4608-4613.
Buglino, Onwueme, Ferreras, Quadri, and Lima (2004).Crystal structure of PapA5, a phthiocerol dimycocerosyl transferase from Mycobacterium tuberculosis. J. Biol. Chem.279:30634-30642.
Palma, DeLuca, Worgall, and Quadri (2004). Transcriptome analysis of the response of Pseudomonas aeruginosa to hydrogen peroxide. J. Bacteriol. 186:248-252.
Quadri (2003). Regulation of Class II bacteriocin production by cell-cell signaling. J. Microbiol. 41:175-182.
Palma, Worgall, and Quadri (2003). Transcriptome analysis of the Pseudomonas aeruginosa response to iron. Arch. Microbiol.180:374-379.
Quadri (2002). Regulation of antimicrobial peptide production by autoinducer-mediated quorum sensing in lactic acid bacteria. Antonie Van Leeuwenhoek 82:133-145.
Kleerebezem, Kuipers, de Vos, Stiles, and Quadri (2001).A two-component signal-transduction cascade in Carnobacterium piscicola LV17B: two signaling peptides and one sensor-transmitter. Peptides22:1597-1601.
Kleerebezem and Quadri (2001). Peptide pheromone-dependent regulation of antimicrobial peptide production in Gram-positive bacteria: a case of multicellular behavior. Peptides22:1579-1596.
Quadri (2000). Assembly of aryl-capped siderophores by modular peptide synthetases and polyketide synthases. Mol. Microbiol. 37:1-12.
Quadri, Keating, Patel, and Walsh (1999). Assembly of the Pseudomonas aeruginosa nonribosomal peptide siderophore pyochelin: In vitro reconstitution of aryl-4,2-bisthiazoline synthetase activity from PchD, PchE and PchF. Biochemistry 38:14941-14954.
Franz, Worobo, Quadri, Schillinger, Holzapfel, Vederas, and Stiles (1999). Atypical genetic locus for enterocin B production in Enterococcus faecium BFE 900. Appl. Environ. Microbiol. 65:2170-2178.
Quadri, Sello, Keating, Weinreb, and Walsh (1998). Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. Chem. Biol. 5:631-645.
Quadri, Weinreb, Lei, Nakano, Zuber, and Walsh (1998). Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. Biochemistry 37:1585-1595.
Weinreb, Quadri, Walsh, and Zuber (1998). Stoichiometry and specificity of in vitro phosphopantetheinylation and aminoacylation of the valine-activating module of surfactin synthetase. Biochemistry 37:1575-1584.
Walsh, Gehring, Weinreb, Quadri, and Flugel (1997). Post-translational modification of polyketide and nonribosomal peptide synthases. Curr. Opin. Chem. Biol. 1:309-315.
Quadri, Kleerebezem, Kuipers, de Vos, Roy, Vederas, and Stiles (1997). Characterization of a locus from Carnobacterium piscicola LV17B involved in bacteriocin production and immunity: evidence for global inducer-mediated transcriptional regulation. J. Bacteriol. 179:6163-6171.
Kleerebezem, Quadri, Kuipers, and de Vos (1997). Quorum sensing by peptide pheromones and two-component signal-transduction systems in Gram-positive bacteria. Mol. Microbiol.24:895-904.
Quadri, Yan, Stiles, and Vederas (1997). Effect of amino acid substitutions on the activity of carnobacteriocin B2. Overproduction of the antimicrobial peptide, its engineered variants, and its precursor in Escherichia coli. J. Biol. Chem. 272:3384-3388.
Quadri, Sailer, Terebiznik, Roy, Vederas, and Stiles (1995). Characterization of the protein conferring immunity to the antimicrobial peptide carnobacteriocin B2 and expression of carnobacteriocins B2 and BM1. J. Bacteriol. 177:1144-1151.
Quadri, Sailer, Roy, Vederas, and Stiles (1994). Chemical and genetic characterization of bacteriocins produced by Carnobacterium piscicola LV17B. J. Biol. Chem. 269:12204-12211.
Quadri and Giulietti (1993). Effect of elicitation on the accumulation of solasodine by immobilized cells of Solanum eleagnifolium Cav.Enz. Microb. Technol. 15:1074-1077.
