Jean E. Sealey D.Sc.
Key References from 186 original publications, 84 book chapters and review articles:

LARAGH JH, SEALEY JE, SOMMERS SC. (1966) Patterns of adrenal secretion and urinary excretion of aldosterone and plasma renin activity in normal and hypertensive subjects. Circ. Res. 18 & 19 (Suppl I): 158 174.

SEALEY JE, CLARK I, BULL MB, LARAGH JH. (1970) Potassium balance and the control of renin secretion. J Clin Invest 49: 2119 2127

BRUNNER HR, KIRSHMAN JD, SEALEY JE, LARAGH JH. (1971) Hypertension of renal origin: evidence for two different mecha?nisms. Science 174: 1344 1346.

SEALEY JE, GERTEN BANES J, LARAGH JH. (1972) The renin system: variations in man measured by radioimmunoassay or bioassay. Kidney International l: 240 253.

LARAGH JH, BAER L, BRUNNER HR, B?HLER FR, SEALEY JE, VAUGHAN ED, Jr. (1972) Renin, angiotensin and aldosterone system in pathogenesis and management of hypertensive vascular disease. Am J Med. 52: 633 652.

SEALEY JE, B?HLER FR, LARAGH JH, MANNING EL, BRUNNER HR. (1972) Aldosterone excretion: physiologic variations in man measured by radioimmunoassay or double isotope dilution. Circ. Res. 31: 367 378.

BRUNNER HR, SEALEY JE, LARAGH JH. (1973) Renin subgroups in essential hypertension: further analysis of their pathophysiologic and epidemiologic characteristics. Circ. Res. 32 & 33 (Suppl I): 99 109.

SEALEY JE, B?HLER FR, LARAGH JH, VAUGHAN ED Jr. (1973) The physiology of renin secretion in essential hypertension: estimation of renin secretion rate and renal plasma flow from peripheral and renal vein renin levels. Am J Med. 55: 391 401.

SEALEY JE, LARAGH JH. (1973) Searching out low renin patients: limitations of some commonly used methods. Am J Med. 55: 303 314.

VAUGHAN ED, B?HLER FR, LARAGH JH, SEALEY JE, BAER L, BARD RH. (1973) Renovascular hypertension: renin measurements to indicate hypersecretion and contralateral suppression, estimate renal plasma flow, and score for surgical curability. Am J Med. 55: 402 414.

BRUNNER HR, SEALEY JE, LARAGH JH. (1973) Renin as a risk factor in essential hypertension: more evidence. Am J Med. 55: 295 320.

LARAGH JH, SEALEY JE, B?HLER FR, VAUGHAN ED JR, BRUNNER HR, GAVRAS H, BAER L. (1975) The renin axis and vasoconstriction volume analysis for understanding and treating renovascular and renal hypertension. Am J Med. 58: 4 13.

SEALEY JE, LARAGH JH. (1975) Prorenin in human plasma? Methodological and physiological implications. Circ. Res. 36 & 37 (Suppl I): 10 16.

CASE DB, WALLACE JM, KEIM HJ, WEBER MA, SEALEY JE, LARAGH JH. (1977) Possible role of renin in hypertension as suggested by renin sodium profiling and inhibition of converting enzyme. N Engl. J Med. 296: 641 646.

SEALEY JE, MOON C, LARAGH JH, ATLAS SA. (1977) Plasma prorenin in normal, hypertensive and anephric subjects and its effect on renin measurements. Circ. Res. 40 (Suppl I): 41 45.

ATLAS SA, SEALEY JE, LARAGH JH, MOON C. (1977) Plasma renin and "prorenin" in essential hypertension during sodium depletion, beta blockade and reduced arterial pressure. Lancet II, 785 789.

SEALEY JE, WHITE RP, LARAGH JH, CASE DB, RUBIN AL. (1978) Studies of plasma aldosterone in anephric people: evidence for fundamental role of the renin system in maintaining aldosterone secretion. J Clin. Endocrinol. Metab. 47: 52 60.

SEALEY JE, McCORD D, TAUFIELD PA, ALES KA, DRUZIN ML, ATLAS SA, LARAGH JH. (1985) Plasma prorenin in first trimester pregnancy: relationship to changes in human chorionic gonadotropin. Am J Obstet Gynecol 153:514 519.

SEALEY JE, ATLAS SA, GLORIOSO N, MANAPAT H, LARAGH JH. (1985) Cyclical secretion of prorenin during the menstrual cycle: Synchronization with luteinizing hormone and progesterone. Proc. Nat'l. Acad. Sci. USA 82:8705 8709

MUELLER FB, SEALEY JE, CASE DB, ATLAS SA, PICKERING TG, PECKER MS, PREIBISZ JJ, LARAGH JH. (1986) The captopril test for identifying renovascular disease in hypertensive patients. Am J Med. 80: 633 644.

SEALEY JE, CHOLST I, GLORIOSO N, TROFFA C, WEINTRAUB ID, JAMES G, LARAGH JH. (1987) Sequential changes in plasma luteinizing hormone and plasma prorenin during the menstrual cycle. J Clin. Endocrinol. Metab. 63: 1 5.

SEALEY JE, GOLDSTEIN M, PITARRESI T, KUDLAK TT, GLORIOSO N, FIAMENGO SA, LARAGH JH. (1988) Prorenin secretion from human testis: no evidence for secretion of active renin or angiotensinogen. J Clin Endocrinol Metab 66: 974 978.

LARAGH JH, LAMPORT B, SEALEY JE, ALDERMAN MH. (1988) Diagnosis ex juvantibus: individual response patterns to drugs reveal hypertension mechanisms and simplify treatment. Hypertension 12: 223 226.

SEALEY JE, BLUMENFELD JD, BELL GM PECKER MS, SOMMERS SC, LARAGH JH. (1988) On the renal basis for essential hypertension: nephron heterogeneity with discordant renin secretion and sodium excretion. J Hypertension 6: 763 777.

LENZ T, SEALEY JE, LAPPE RW, CARILLI C, OSHIRO GT, BAXTER JD, LARAGH JH. (1990) Infusion of recombinant human prorenin into rhesus monkeys: effects on hemodynamics, renin-angiotensin-aldosterone axis and plasma testosterone. Am J Hypertens 3: 257-261.

ALDERMAN M, MADHAVAN S, OOI WL, COHEN H, SEALEY JE, LARAGH JH. (1991) Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension N Engl. J Med. 324: 1098-1104.

SEALEY JE. (1991) Plasma renin activity and plasma prorenin assays. Clin. Chem. 37: 1811-1819.

PITARRESI T, RUBATTU S, SEALEY JE. (1992) Reversible cryoactivation of recombinant human prorenin. J Biol. Chem. 17: 11753-11759

ITSKOVITZ J, BRUNEVAL P, SOUBRIER R, CORVOL P, SEALEY JE. (1992) Localization of renin gene expression to monkey ovarian thecal cells by in situ hybridization. J Clin Endocrinol Metab. 75: 1374-1380

Von LUTTEROTTI N, CATANZARO DF, SEALEY JE, LARAGH JH. (1994) Renin is not synthesized by cardiac and extrarenal vascular tissues: a review of experimental evidence. Circulation 89:458-470

SEALEY JE, TRENKWALDER P, GAHNEM F, CATANZARO DF, LARAGH JH. (1995) Plasma renin methodology: inadequate sensitivity and accuracy of direct renin assay for clinical applications compared with the traditional enzymatic PRA assay. (Commentary) J. Hypertens. 13:27-30

SEALEY JE, LARAGH JH. (1996) Renin and prorenin: advances and declines in methodology. Clin. Chem. 42:(6) 1-2.

TRENKWALDER P, JAMES GD, LARAGH JH, SEALEY JE. (1996) Plasma renin activity and plasma prorenin are not suppressed in hypertensives surviving to old age. Am. J. Hypertens. 9: 621-627.

BRAGAT AC, BLUMENFELD J, SEALEY JE: (1997) Effect of high performance liquid chromatography on plasma angiotensin II measurements in treated and untreated normotensive and hypertensive patients. J. Hypertens. 15:459-465.

ALDERMAN MH, OOI WL, COHEN H, MADHAVAN S, SEALEY JE, LARAGH J: (1997) Plasma renin activity: a risk factor for myocardial infarction in hypertensive patients. Am. J. Hypertens. 10:1-8

ITSKOVITZ-ELDOR J, KOL S, LEWIT N, SEALEY JE. (1997) Ovarian origin of plasma and peritoneal fluid prorenin in early pregnancy and in patients with ovarian hyperstimulation syndrome. J.Clin.Endocrinol.Metab. 82:461-464

HU L, CATANZARO DF, PITARESSI TM, LARAGH JH, SEALEY JE: (1998) Identical hemodynamic and hormonal responses to 14 day infusions of renin or angiotensin II in conscious rats. J. Hypertens. 16:1285-1298

BLUMENFELD JD, SEALEY JE, MANN SJ, BRAGAT A, MARION R, PECKER MS, SOTELO J, AUSUST P, PICKERING TG, LARAGH JH (1999). Beta-Adrenergic receptor blockade as a therapeutic approach for suppressing the renin-angiotensin-aldosterone system in normotensive and hypertensive subjects. Am. J. Hypertension 12:451-459.

HU L, CATANZARO DF, LARAGH JH, SEALEY JE. (1999). Delayed recovery of hypertension after single dose losartan in angiotensin II-infused conscious rats. J. Hypertens 17:1443-1450.

BLUMENFELD JD, SEALEY JE, ALDERMAN MH, COHEN H, LAPPIN R, CATANZARO DF, LARAGH JH. (2000) Plasma renin activity in the emergency department and its independent association with acute myocardial infarction. Am. J. Hypertension 13: 855-863.

LARAGH JH, SEALEY JE: (2001) K (+) depletion and the progression of hypertensive disease of heart failure. The pathogenic role of diuretic-induced aldosterone secretion. Hypertension. 37:806-810.

LARAGH JH, SEALEY JE: (2003) Relevance of the plasma renin hormonal control system that regulates blood pressure and sodium balance for correctly treating hypertension and for evaluating ALLHAT. Am. J. Hypertens. 16:407-415.

ALDERMAN MH, COHEN HW, SEALEY JE, LARAGH JH: (2004) Plasma renin activity levels in hypertensive persons: their wide range and lack of suppression in diabetic and in most elderly patients. Am. J. Hypertens. 17:1-7.

RESNICK LM, CATANZARO DF, SEALEY JE, LARAGH JH: (2004) Acute vascular effects of the angiotensin II receptor antagonist olmesartan in normal subjects: relation to the renin-aldosterone system. Am. J. Hypertension 17: 203-208.

HU L, SEALEY JE, CHEN R, ZHOU Y, MERALI C, SHI Y, LARAGH JH, CATANZARO DF: (2004) Nitric oxide synthase inhibition accelerates the pressor response to low-dose angiotensin II, exacerbates target organ damage, and induces renin escape. Am. J. Hypertension 17:395-403

SEALEY JE, BLUMENFLED J, LARAGH JH: (2005) Prorenin cryoactivation as a possible cause of normal renin levels in patients with primary aldosteronism. J. Hypertens. 23:459-462

SEALEY JE, GORDON RD, MANTERO F: (2005) Plasma renin and aldosterone measurements in low renin hypertensive states. Trends in Endocrinol. & Metab. 16:86-91

SEALEY JE, ITSKOVITZ-ELDOR J: (2006) ACE inhibitors and major congenital malformations. N.Engl. J. Med. 355:1280-1281

SEALEY JE, LARAGH JH: (2007) Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its usefulness. Am. J. Hypertens. 20:587-597

JONES MR, SEALEY JE, LARAGH JH: (2007) Effects of angiotensin receptor blockers on ambulatory plasma renin activity in healthy normal subjects during unrestricted sodium intake. Am. J. Hypertens. 20:907-916

SEALEY JE, LARAGH JH: (2008) It is the plasma renin activity level that counts, not stoichiometry. Hypertension 52:1-1

LARAGH JH, EGAN BM, SEALEY JE, LACKLAND DT, BASILE JN, REHMAN SU, STRANGE P, GROB C, RIEHLE J, WALTERS C: (2008) A randomized controlled trial of the Laragh Method, a plasma renin test guided drug treatment algorithm for correcting patients with treated but uncontrolled hypertension. J Hypertens 26 (Suppl I): S470