J. David Warren, Ph.D.

• Research
• Honors & Awards
• Publications

Publications

1. J. David Warren and Yian Shi. "Chiral Ketone-Catalyzed Asymmetric Epoxidation of 2,2-Disubstituted Vinyl Silanes" J. Org. Chem. 1999, 64, 7675-7677. DOI: 10.1021/jo990951z
2. J. David Warren, Justin S. Miller, Stacy J. Keding, and Samuel J. Danishefsky. "Toward Fully Synthetic Glycoproteins by Ultimately Convergent Routes: A Solution to a Long-Standing Problem" J. Am. Chem. Soc. 2004, 126, 6576-6578. DOI: 10.1021/ja0491836
3. Ouathek Ouerfelli, J. David Warren, Rebecca M. Wilson, and Samuel J. Danishefsky. "Synthetic Carbohydrate-Based Antitumor Vaccines: Challenges and Opportunities" Expert Rev. Vaccines 2005, 4, 677-685. DOI: 10.1586/14760584.4.5.677
4. Jiehao Chen, J. David Warren, Bin Wu, Gong Chen, Qian Wan, and Samuel J. Danishefsky. "Synthesis of Cyclic Peptides and Glycopeptides by Native Chemical Ligation Using in Situ Derived Thioesters" Tetrahedron Lett. 2006, 47, 1969-1972. DOI: 10.1016/j/tetlet/2006.01.077


5. Zhi-Guang Wang, J. David Warren, Vadim Y. Dudkin, Xufang Zhang, Ulrich Iserloh, Michael Visser, Peter H. Seeberger, Matthias Eckhardt, and Samuel J. Danishefsky. "A Highly Convergent Synthesis of a N-linked Glycopeptide Presenting the H-Type 2 Human Blood Group Determinant" Tetrahedron 2006, 62, 4954-4978. DOI: 10.1016/j.tet.2006.02.080
6. Gong Chen, J. David Warren, Jiehao Chen, Bin Wu, Qian Wan, and Samuel J. Danishefsky. "Studies Related to the Relative Thermodynamic Stability of C-Terminal Peptidyl Esters of O-Hydroxy Thiophenol: Emergence of a Doable Strategy for Non-Cysteine Ligation Applicable to the Chemical Synthesis of Glycopeptides" J. Am. Chem. Soc. 2006, 128, 7460-7462. DOI: 10.1021/ja061588y
7. Bin Wu, Jiehao Chen, J. David Warren, Gong Chen, Zihao Hua, and Samuel J. Danishefsky. "Building Complex Glycopeptides: Development of a Cysteine-Free Native Chemical Ligation Protocol" Angew. Chem. Int. Ed. 2006, 45, 4116-4125. DOI: 10.1002/anie.200600538
8. Bin Wu, J. David Warren, Jiehao Chen, Gong Chen, Zihao Hua, and Samuel J. Danishefsky. "Reiterative Cysteine-Based Coupling Leading to Complex, Homogeneous Glycopeptides" Tetrahedron Lett. 2006, 47, 5219-5223. DOI: 10.1016/j.tetlet.2006.04.132
9. Bin Wu, Zihao Hua, J. David Warren, Krishnakumar Ranganathan, Qian Wan, Gong Chen, Zhongping Tan, Jiehao Chen, Atsushi Endo, and Samuel J. Danishefsky. "Synthesis of the Fucosylated Biantennary N-Glycan of Erythropoietin" Tetrahedron Lett. 2006, 47, 5577-5579. DOI: 10.1016/j.tetlet.2006.05.086
10. J. David Warren, Xudong Geng, and Samuel J. Danishefsky. "Synthetic Glycopeptide-Based Vaccines" Top. Curr. Chem. 2007, 267, 109-141. DOI: 10.1007/128_031
11. Isaac J. Krauss, Joseph G. Joyce, Adam C. Finnefrock, Hong C. Song, Vadim Y. Dudkin, Xudong Geng, J. David Warren, Michael Chastain, John W. Shiver, and Samuel J. Danishefsky. "Fully Synthetic Carbohydrate HIV Antigens Designed on the Logic of the 2G12 Antibody" J. Am. Chem. Soc. 2007, 267, 11042-11044. DOI: 10.1021/ja074804r
12. Rebecca M. Wilson, J. David Warren, Ouathek Ouerfelli, and Samuel J. Danishefsky. "Synthetic Carbohydrate-Based Antitumor Vaccines" in Carbohydrate-Based Vaccines, René Roy, Ed. ACS Symposium Series: Washington, D.C., 2008, 258-292.
13. Jianglong Zhu, J. David Warren, and Samuel J. Danishefsky. "Synthetic Carbohydrate-Based Anticancer Vaccines: the Memorial Sloan-Kettering Experience" Expert Rev. Vaccines 2009, 8, 1399-1413. DOI: 10.1586/erv.09.95
14. Gang Lin, Dongyang Li, Luiz Pedro Sorio de Carvalho, Haiteng Deng, Hui Tao, Guillaume Vogt, Kangyun Wu, Jean Schneider, Tamutenda Chidawanyika, J. David Warren, Huilin Li, and Carl Nathan. "Inhibitors Selective for Mycobacterial Versus Human Proteasomes" Nature 2009, 461, 621-626. DOI: 19.1038/nature08357
15. Weiguo He, Clifford E. Soll, Sivagami Sundaram Chavadi, Guangtao Zhang, J. David Warren, and Luis E. N. Quadri. "Cooperation between a Coenzyme A-Independent Stand-Alone Initiation Module and an Iterative Type I Polyketide Synthase during Synthesis of Mycobacterial Phenolic Glycolipids" J. Am. Chem. Soc. 2009, 131, 16744-16750. DOI: 10.1021/ja904792q
16. Ruslana Bryk, Nancy Arango, Aditya Venugopal, J. David Warren, Yun-Hee Park, Mulchand S. Patel, Christopher D. Lima, and Carl Nathan. "Triazaspirodimethoxybenzoyls as Selective Inhibitors of Mycobacterial Lipoamide Dehydrogenase" Biochemistry 2010, 49, 1616-1627. DOI: 10.1021/bi9016186
17. Anton I. Rosenbaum, Guangtao Zhang, J. David Warren, and Frederick R. Maxfield. "Endocytosis of β-Cyclodextrins is Responsible for Cholesterol Reduction in Niemann-Pick Type C Mutant Cells" Proc. Natl. Acad. Sci. USA, 2010 107, 5477-5482. DOI: 10.1073/pnas.0914309107
18. Indu Menon, Thomas Huber, Sumana Sanyal, Sourabh Banerjee, Patrick Barré, Sam Canis, J. David Warren, John Hwa, Thomas P. Sakmar, and Anant Menon. "Opsin is a Phospholipid Flippase" Current Biology, 2011, 21, 149-153. DOI: 10.1016/j.cub.2010.12.031
19. Luiz Pedro S. de Carvalho, Yan Ling, Chun Shen, J. David Warren, Kyu Y. Rhee. "On the Chemical Mechanism of Succinic Semialdehyde Dehydrogenase (GabD1) from Mycobacterium tuberculosis" Arch. Biochem. Biophys. 2011, 509, 90-99. DOI: 10.1016/j.abb.2011.01.023
20. Silvia Diani-Moore, Yuliang Ma, Erin Labitzke, Hui Tao, J. David Warren, Jared Anderson, Qiuying Chen, Steven S. Gross, and Arleen B. Rifkind. "Discovery and Biological Characterization of 1-(1H-indol-3-yl)-9H-pyrido[3,4-b]-indole as an Aryl Hydrocarbon Receptor Activator Generated by Photoactivation of Tryptophan by Sunlight" Chem.-Biol. Interact. 2011, 193, 119-128. DOI: 10.1016/j.cbi.2011.05.010
21. Roger B. Altman, Daniel S. Terry, Zhou Zhou, Qinsi Zheng, Peter Geggier, Rachel A. Kolster, Yongfang Zhao, Jonathan A. Javitch, J. David Warren, and Scott C. Blanchard. "Cyanine fluorophore derivatives with enhanced photostability" Nat. Methods, 2012, 9, 68-71. DOI: 10.1038/nmeth.1774

PATENTS



1. Samuel J. Danishefsky and J. David Warren. "Method for Preparing Polyfunctionalized Peptides and/or Proteins via Native Chemical Ligation" U.S. Patent 7,635,750 B2, December 22, 2009.
2. Samuel J. Danishefsky, J. David Warren, Jiehao Chen, Bin Wu, Gong Chen, Zhongping Tan, Cindy Kan, Yu Yuan, Zihao, Hua, Krishnakumar Ranganathan, John Trzupek and Qian Wan. "Homogeneous Erythropoietin and Other Polyfunctional Peptides and Proteins, Methods and Intermediates for Their Preparation" PCT Int. Appl 2007, WO2007120614 (A2).
3. Scott C. Blanchard, J. David Warren, and Roger Altman. "Method of Tuning Fluorescent Dye Properties and Improved Dyes" PCT Int. Appl. 2009, US2009153871.