Clinical Profile

Publications

1. Boockvar JA, Black K, Malik S, Stanek A, Tracey KJ.:& Subacute paraparesis induced by venous thrombosis of a spinal angiolipoma.& Spine 22:2304-2308, 19972.

2.Boockvar JA, Kotzen RA, Swanson R, Milhorat TH.:& Post-traumatic meningioma: case report and historical perspective.& J Neurol Neurosurg Psych 66: 796-798, 1999

3. Boockvar JA, Virella A, Kotapka M, Flamm ES, Grady MS.:& Neurosurgery at the University of Pennsylvania Medical Center.& Neurosurgery 46 (5): 1223-1228, 2000

4. Boockvar JA, Shafa B, Forman M, O'Rourke D.:& Symptomatic lateral ventricular ependymal cysts: Criteria for distinguishing these rare cysts from other symptomatic cysts of the ventricles. Case Report.& Neurosurgery 46(5): 1229-1233, 2000

5.Telfeian AE, Boockvar JA, Simuni T, Jaggi J, Skolnick B, Baltuch GH:& Efficacy of unilateral deep brain stimulation of the VIM nucleus of the thalamus in a patient with bipolar disorder associated with Klinefelter's syndrome and essential tremor.& Journal of Neurosurgery 93: 127-128, 2000

6. Boockvar JA, Telfeian AE, Baltuch GH, Skolnick B, Simuni T, Stern M, Schmidt L, Trojanowski JQ.:& Long-term deep brain stimulation in a patient with essential Tremor: clinical response and postmortem correlation with stimulator termination sites in ventral thalamus. Journal of Neurosurgery 93: 140-144, 2000

7. Boockvar JA, Phillips MF, Telfeian AE, O'Rourke D, Marcotte PJ.& Results and risk & & & & factors for anterior cervicothoracic junction surgery. Journal of Neurosurgery Spine 94: 12-17, & 2001

8. Boockvar JA, Zager EL:& Surgical management of cubital tunnel syndrome.& In Thieme's (ed):& Seminars in Neurosurgery, Vol. 12 (1): 57-63, 2001

9. Boockvar JA, Loudon W, Sutton LN.& The development of the Spitz-Holter valve in & & & & & & Philadelphia.& Journal of Neurosurgery 95: 145-147, 2001

10. Boockvar JA, Durham S, Sun P.& Congenital cervical spinal stenosis and sports-related cervical cord neurapraxia in children. Spine 26 (24): 2709-2712, 2001

11. Riess P, Zhang C, Saatman K, Laurer HL, Teng T, Bareyre FM, Raghupathi R, Lenzlinger P, Longhi L, Lifshitz J, Neugebauer E, Boockvar JA, Snyder E, McIntosh TK.& Transplanted neural stem cells survive, differentiate and improve neurologic motor function after experimental traumatic brain injury. Neurosurgery 51 (4): 1-11, 2002

12. Yip S, Aboody KS, Burns M, Imitola J, Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M, McIntosh T, O'Rourke DM, Khoury S, Weissleder R, Black PM, Weiss W, Snyder EY. Neural stem cell biology may be well suited for improving brain tumor therapies. Cancer J 9(3):189-204, 2003

13. Boockvar JA, Kapitonov D, Schouten J, Counelis GJ, Kapoor G, Bogler O, Snyder E, McIntosh T, O'Rourke DM. Constitutive EGFR signaling confers a motile phenotype to neural stem cells.& Molecular and Cellular Neuroscience 24, (4): 1116-1130, 2003

14. Boockvar JA, Stiefel M, Malhotra N, Dolinskas C, Dwyer-Joyce C, LeRoux PD.& Dural Cavernous angioma of the posterior sagittal sinus: case report.& Surgical Neurology 63: 178-181, 2005

15. Boockvar JA, Schouten J, Royo N, Millard M, Spangler Z, Castelbuono D, Snyder E, O'Rourke D, McIntosh T.& Experimental traumatic brain injury modulates the survival, migratory and terminal phenotype of transplanted EGFR activated neural stem cells Neurosurgery 56: 163-71, 2005

16. Ayuso, A., Greenfield JP., Graham, C., Boockvar, JA.& The duality of EGFR signaling and neural stem cell phenotype:& Cell enhancer or cell transformer?& Current Stem Cell Research and Therapy, 2: 231-238, 2006

17. Fraser, J., Hartl, R., Boockvar, JA. & Intervertebral Disc Transplantation:& Treatment in Motion.& Neurology Alert, vol 4, 20-22, 2007

18. Fraser, J., Hartl, R., Boockvar, JA. & SPORTing Statistics:& Slicing the Drive on Appropriate Treatment.& Neurology Alert, vol 2, 9-12, 2007

19. Bleau A, Howard, B, Taylor L, Gursel D, Tung L, Greenfield, J, Holland EC, Boockvar, JA.& A new strategy for analysis of phenotypic marker antigens in murine and human brain tumor derived neurospheres, , Neurosurg Focus, 24 1-9, March/April 2008&

20. Wong K, Ayuso-Sacido A, Anhow P, Boockvar JA and Wu M. Assessing neural stem cell motility using an agarose gel based microfluidic device,& Journal of Visualized Experiments, Vol 1, 2008

21. Ayuso, A., Greenfield, JP., Roy NS., Schwartz TH., Boockvar, JA.& Long-term isolation of adult human brain subventricular zone precursors, in press, Neurosurgery, 2008 Jan: 62(1):223-9.

22. Greenfield J, Ayuso-Sacido A, Panullo S, Schwartz T, Souweiddane M, , Stieg P, Boockvar JA. Use of human neural tissue& for the generation of progenitors, Neurosurgery 2008 Jan: 62(1):21-37

23. Howard BM, Boockvar JA, Dunn IF, Friedlander RM.& Pluripotential stem cells from mature somatic cells.& Neurosurgery. 2008 Feb; 62 (2): N6-7.&

24. Howard B, Boockvar JA.& Magnetic Resonance Spectroscopy Traces Neural Progenitor Cells in Vivo.& Neurosurgery. 2008 Apr: 62(4):N12

25. Greenfield JP, Howard BM, Huang C, Boockvar JA. Endoscopic Endonasal Transsphenoidal Surgery using a Skull Reference Array and Laser Surface Scanning. Minimally Invasive Neurosurgery. 51: 244-246. 2008.

26. Greenfield JP, Boockvar JA.& Stem Cell migration in a novel model to study pediatric brain tumors.& Neurosurgery. 2008 Aug;63(2): N9

27. Beyene R, Boockvar JA.& Disease-specific induced pluripotent stem cells.& Neurosurgery.& 2008; 63(6):12.

28. Parikh K, Tomasino A, Knopman J, Boockvar JA, Hartl R. Operative Results and Learning Curve with Microscope-Assisted Tubular Microsurgery for one and two discectomies and laminectomy.& Neurosurg Focus, 25, 2: 1-6 2008

29. Hofstetter C, Howard B,& Gursel D, Boockvar JA. EGFR signaling is differentially active in brain tumor stem cells.(in revision)

30. Hofstetter C, Howard B, Gursel D, Lavi E, Boockvar JA. Molecular Profile of Glioblastoma Multiforme in a rare case of Turcot´s syndrome. (in revision)

31. Knopman,J., Desai,NS., Seedial, S., Mubita L., Huang, C., Boockvar,JA. Free nasoseptal mucosal flap for endoscopic endonasal transphenoidal skull base surgery: Results and operative technique. (in revision)

32. Howard B, Boockvar JA. Brain tumor stem cells: will understanding a new paradigm lead to improved therapies? Expert Rev. Neurotherapeutics 8(4), 159-160 (2008)

33. Knopman J, Sigounas D, Kacker A, Schwartz TH, Boockvar, JA.& Combined Supraciliary and Endoscopic Endonasal Approach for Resection of Frontal Sinus Mucoceles: Technical Note.& Minim Invasiv Neurosurg 2009; 52: 1-3

34. Beyene, R., Boockvar, JA.& Novel Treatment of Glioblastoma Multiforme Tumor Stem Cells with Oncolytic Viruses.& July 2009: 65:1 Neurosurgery

35. Howard BM, Hofstetter C, Wagner P, Muskin ET, Lavi E, Boockvar JA.
Transformation of low grade pineal parenchymal tumor to secondary pineoblastoma. Neuropathology and Applied Neurobiology (2009), 35, 214–217

36. Beyene R, Howard BM, BoockvarJA.& Stem cell populated implanted trachea.& Neurosurgery. 2009 May;64 (5): N12-3

37. Wernicke Ag, Sherr Dl, Schwartz TH, Pannullo SC, Stieg PE, Boockvar JA, Moliterno JA, Ivanidze J, Trichter S, Sabbas AM, Parashar B, Nori D.& The role of dose escalation with intracavitary brachytherapy in the treatment of localized CNS malignancies:& Outcomes and toxicities of a prosepctive study.& Brachytherapy (2009), Oct 20

38. Ayuso-Sacido A, Moliterno JA, Kratovac S, Kapoor GS, O'Rourke DM, Holland EC, García-Verdugo JM, Roy NS, Boockvar JA.& Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells. J Neurooncol. 2009 Oct 24.

39. Hofstetter C, Boockvar JA& Reduction of Seizures by Transplantation of Embryonic GABAergic Interneurons Into Kv1.1 Mutant Mice.& Neurosurgery N8-9; 65: 6, December 2009.

40. Neal Luther, Ioannis Karampelas, Eleni P. Souliopoulos, Mark A. Edgar, Boockvar JA& and Mark M. Souweidane Interstitial infusion of erlotinib in the rodent brain Journal of Experimental Therapeutics and Oncology Vol: 8, 2, 2009 p. 79-84

41.& Riina H.A.,& Fraser J.F., Fralin S., Knopman J., Scheff R.J. and Boockvar JA. Superselective intraarterial cerebral infusion of bevacizumab:a revival of interventional neuro-oncology for malignant glioma Journal of Experimental Therapeutics and Oncology Vol: 8, 2, 2009 p. 145-150.

42. Tomasino A, Parikh K, Steinberger J, Knopman J, Boockvar JA,& Hartl R.& Spine. Tubular microsurgery for lumbar discectomies and laminectomies in obese patients; operative results and outcome. (Phila Pa 1976). 2009 Aug 15;34(18): E664-72.

43. Hofstetter CP, Boockvar JA.Stem cell based growth factory delivery to the injured spinal cord Neurosurgery, 2010 Feb;66(2): N16-7

44. Boockvar JA, Hofstetter CP, Forcing stem cells to an end. Neurosurgery. 2010 Apr;66(4):N17-8.

45. Wernicke AG, Sherr DL, Schwartz TH, Pannullo SC, Stieg PE, Boockvar JA, Ivanidze J, Moliterno JA, Parashar B, Trichter S, Sabbas AM, Nori D. Feasibility and safety of GliaSite brachytherapy in treatment of CNS tumors following neurosurgical resection. & J Cancer Res Ther. 2010 Jan-Mar;6(1):65-74

46. Boockvar JA, Gobin YP, Greenfield JP, Fralin S, Knopman J, Riina HA,& Tsiouris AJ, Souweidane MM. Ballon-assisted superselective intra-arterial cerebral infusion of Bevacizumab for malignant brainstem gliomas. A technical note. Interv Neuroradiol. 2010 Mar;16(1):71-6. Epub 2010 Mar 25

47.Boockvar JA, Huang C, Mubita LL, Moliterno JA. High-viscosity polymethylmethacrylate cement for endoscopic anterior cranial base reconstruction.& J Neurosurg. 2010 Mar 26. [Epub ahead of print]

& 48. Cohan JN, Moliterno JA, Mok, CL, Lavi E, Boockvar JA. Pineal parenchymal tumor of intermediate differentiation with papillary features: a continuum of primary pineal tumors. J Neurooncol. 2010 Jun 3.& [Epub ahead of print]

49. Boockvar JA, Hofstetter CP, Neural stem cells: targeting gliomas in 3-dimensions. Neurosurgery. 2010 Jun;66(6):N15.

50. & Aaker GD, Boockvar JA, Cohan JN, Härtl R, Huang QD, Grivoyannis AD, Knopman J, Parikh K, Patel AR, Moliterno JA. Results and risk factors for recurrence following single-level tubular lumbar microdiscectomy. J Neurosurg Spine.2010 Jun;12(6):680-6.

51. Howard B, Hofstetter C, Gursel D, Boockvar JA. EGFR signaling is differentially activated in patient-derived glioblastoma stem cells.J Exp Ther Oncol. 2010;8(3): 247-60

52. Luther N, Karampelas I, Souliopoulos E, Edgar M, Boockvar JA, Souweidane M. Interstitial infusion of erlotinib in the rodent brain. Journal of Experimental Therapeutics and Oncology. Vol. 8, 2, 2010 p. 79-84

53. Boockvar JA, Hofstetter C, Electrical stimulation of the thalamus modulates cortico-cortical signaling. J Neurosurg. Dec 2010; Vol. 67 p. 21-24

54. Boockvar JA, Cohan JN, Lavi E, Moliterno JA, Mok, CL, Pineal parenchymal tumor of intermediate differentiation with papillary features: a continuum of primary pineal tumors? J Neurooncol. Jan 2011; Vol. 101 p. 301-310

55.Allen BB, Beyene R., Boockvar JA, Bukanova EN, Fatoo A, Nanaszko MJ, Mok CL, Moliterno JA. Understandind the role of tumor stem cells in glioblastoma multiforme: a review article. J Neurooncol. 2010 Sep. [Epub ahead of print]

56. Boockvar JA, Tsioris J, Hofstetter C et al. Safety and Maximum tolerated dose of superselective intraarterial cerebral infusion of Bevacizumab after Osmotic blood brain barrier disruption for recurrent malignant glioma. Journal of Neurosurgery. Nov, 2010 [Epub ahead of print]

57. Hofstetter C, Boockvar JA.& Generation of neural stem cells: a team approach. Neurosurgery, Dec 2010; 67 (6): N22-3.

58. Gursel D, Beyene R, Greenfield, Souweidane MM, Kaplitt M, Arango-Lievano M. Howard B, Boockvar JA. Optimization of Glioblastoma Multiforme Stem cell Isolation, Transfection and Transduction. J Neurooncol. 2011 Feb 19

59. Santillan A, Zink W, Lavi E, Boockvar JA, Gobin YP, Patsalides A, Endovascular embolization of cervical hemangiopericytoma with Onyx-18: case report and review of the literature. J NeuroIntervent Surg (2010)

60. Hofstetter CP, Shin BJ, Mubita L, Huang C, Anand VK, Boockvar JA, Schwartz TH Endoscopic endonasal transsphenoidal surgery for functional pituitary adenomas. Neurosurg Focus. 2011 Apr;30(4):E10

61. Gürsel DB, Shin BJ, Burkhardt JK, Kesavabhotla K, Schlaff CD, Boockvar JA. Glioblastoma Stem-Like Cells-Biology and Therapeutic Implications. Cancers (Basel). 2011 Jun 10;3(2):2655-2666. PubMed PMID: 21796273.

62. Burkhardt J, Kesavabhotla K, Schlaff C, Hofstetter CP, Riina HA, Boockvar JA. Cost Analysis of Intra-arterial versus Intra-venous Delivery of Bevacizumab for the Treatment of Recurrent Glioblastoma Multiforme. JETO 2011

63.. Burkhardt J, Kesavabhotla K, Schlaff C, Hofstetter CP, Riina HA, Fralin S, Boockvar JA. Intra-Arterial Delivery of Bevacizumab after Blood Brain Barrier Disruption for the Treatment of Recurrent Glioblastoma: Progression Free Survival and Overall Survival. World Neurosurgery 2011.

64. Hofstetter CP, Burkhardt J, Gursel D, Shin B, Holand EC, Boockvar JA. Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia. PloS ONE 2011 (in press)

65. Shin B, Burkhardt JK, Boockvar J. Glioblastoma Multiforme Stem-Like Cells and Hypoxia: The Novel Role of HAF. Neurosurgery. 2011 Oct;69(4):N21. PubMed PMID: 21900808.

Books, Book Chapters and Reviews
&

  1. Fraser JF, Boockvar JA, Hartl R. Traumatic Injury of the Spine, in JA Norton, PS Barie, RR Bollinger et al. (eds): Surgery. Basic Science and Clinical Evidence. New York, NY: Springer, 2008.
  2. Boockvar JA, LeRoux P:& Meningeal Neoplasms with Aggressive Behavior. In Wilken's and Rengencary (ed):& Neurosurgery (3rd edition).& Lippencott, Williams and Wilkens, Baltimore, 2003&
  3. Boockvar JA, Judy K.:& Surgery for hemispheric gliomas. In Stein S (ed): Neurobase: Surgical Edition. San Diego: Arbor Publishing Corp, 1999

Invited Published Commentaries
&

  1. Boockvar, JA.& California Stem Cell Initiative.& Science Times, Neurosurgery, Vol. 56: 1, N7, 2005
  2. Boockvar, JA.& Autologous Adipose-derived Stem Cells and Fibrin Glue Used to Treat Widespread Traumatic Calvarial Defects. Science Times, Neurosurgery, Vol. 56: 3, N9, 2005
  3. Boockvar, JA.& Bone marrow derived stem cells for boney fusion.& Science Times, Neurosurgery, Vol. 56: 3, N9, 2005
  4. Ayuso, A. Boockvar, JA.& Allodynia limits the usefulness of intraspinal neural stem cell grafts.& Science Times, Neurosurgery, Vol. 56: 3, N9, 2005
  5. Greenfield, J.& Boockvar, JA.& Patient derived embryonic stem cells.& Science Times, Neurosurgery, Vol. 57: 4, N9, 2005
  6. Greenfield, J. Boockvar, JA. Is there a Glioma Stem Cell?& Science Times, Neurosurgery, Vol. 57: 6, N7, 2005
  7. Boockvar, JA.& Hair follicle stem cells support repair of severed peripheral nerves, Neurosurgery, Vol. 58: 2, N9 2006
  8. Greenfield, J. Boockvar, JA. Fallibility of GBM cell lines overcome by use of tumor derived stem cell lines, Neurosurgery Vol 59: 2, N9 2006
  9. Greenfield J, Boockvar, JA.& Neurocytoma Is a Tumor of Adult Neuronal Progenitor Cells Neurosurgery Vol 60: 2, 8N9 2007
  10. Greenfield J, Boockvar, JA.& Repairing Damage within the Subventricular Zone Neurosurgery Vol 60: 4 N6 2007
  11. Greenfield J, Boockvar, JA.& Activation of Early Glial Progenitors in Multiple Sclerosis Neurosurgery Vol 60: 6 N7 2007
  12. Greenfield J, Boockvar, JA.& The Origins of Brain Tumor Stem Cells.& Neurosurgery Vol 61: 3 N12 2007
  13. Greenfield JP, Howard BM, Boockvar JA. (2007) Notch signaling helps determine neural stem cell fate. Neurosurgery. 61(6): N10.
  14. Howard BM and Boockvar JA. CD133 Status Predicts Outcome in Glioma Patients. Neurosurgery. Summer, 2008.

Selected Abstracts
&

  1. Boockvar JA, Murthy J, Ivanova S, Meistrell M, Botchkina G, Tracey KJ.& Brain TNF production mediated by the cytotoxin 3-aminopropanal. The American Association of Neurological Surgeons, Denver, Colorado, April 1997.
  2. Boockvar JA.& Post-Traumatic meningioma: Current controversy and historical perspective.& The American Association of Neurological Surgeons, Philadelphia, PA, April 1998.
  3. Boockvar JA, Durham S, Sun P.& Congenital cervical spinal stenosis and sports-related cervical cord neurapraxia in children.& The AANS/CNS Section on Pediatric Neurological Surgery, San Diego, CA, December 2000
  4. Boockvar JA.& Neural stem cells:& A strategy for gene therapy and CNS repair.& Philadelphia Neurological Society, Philadelphia, PA, March 2001
  5. Boockvar JA, Bogler O, Kapitonov D, Ma L, O'Rourke DM.& EGFR signaling affects fate choices and neural stem cell phenotype. Developmental Brain Research 134 (2002) A14
  6. Boockvar JA, Bogler O, Kapitonov D, Ma L, O'Rourke DM.& Alteration of EGFR signaling and neural stem cell phenotype.& The American Association of Neurological Surgeons, Chicago, Illinois, April 2002
  7. Boockvar JA, Counelis G, Bogler O, O'Rourke DM. Cooperative signaling between EGFR and myc in modulating neural stem cell phenotype.& The American Association of Neurological Surgeons, Section on Tumors, Chicago, Illinois, April 2002
  8. Boockvar JA, Counelis G, Kapitonov D, Bogler O, Shouten J, Grady MS, McIntosh T, O'Rourke, D. Constitutive EGFRvIII signaling and neural stem cell phenotype. The Congress of Neurosurgeons, Philadelphia, PA September 2002
  9. Boockvar JA, Schouten J, Shimuzo S, Millard M, Patel M, Hoover R, Snyder E, O'Rourke D, McIntosh TK.& Activated EGFR signaling and transplanted neural stem cell motility. Journal of Neurotrauma 19 (10): 1276, 2002
  10. Wells Roth D, Hartl R, Boockvar JA.& Minimally invasive spinal fusion with unilateral pedicle screw fixation for single level degenerative spine disease.& AANS, San Francisco, 2006
  11. Ayuso-Sacido A, Kapitonov D, Graham C, Ahmad FS,& Boockvar JA.& Development of an adult human neural stem cell bank. AANS, San Francisco, 2006
  12. Ayuso-Sacido A, Kapitonov D, Graham C, Ahmad FS, Boockvar JA. Characterization of a new cell based system to evaluate the EGFR signaling influence in neural stem cells phenotype determination.& ISSCR, Toronto 2006
  13. Cheng C, Dattatreyudu N, Li G, Ayuso-Sacido A, Boockvar JA.& Cytotoxicity of Statins on Glioblastoma cells with varying levels of EGFR signaling.& Society for Neuro-oncology, Orlando, 2006
  14. Ionnis, Boockvar JA, Soweiddane M.& Erlotinib, a small molecule Epidermal Growth Factor Receptor (EGFR) inhibitor, does not cause direct cytotoxicity to rodent naïve brain following its administration by Convection-Enhanced Delivery: Implications for Glioma Therapy& Society for Neuro-oncology, Orlando, 2007
  15. Howard B, Tung, HYL, Ayuso-Sacido A, Boockvar JA.& & Genetic variations in brain tumors effect sensitivity to Erlotinib.& , Society for Neuro-oncology, Orlando, 2007
  16. Moliterno J, Boockvar JA.& EGFR Activation Suppresses the Expression of the Catalytic Subunit of PP2A in Human GBM, San Diego, 2009
  17. Fatoo A, Boockvar JA.& Transfection of GBM Tumor Stem Cells with Iron Nanoparticles for MRI tracking:& Cell Viability, Differentiation, and Intracellular Localization, San Diego, 2009
  18. Moliterno J, Boockvar JA.& High Viscoscity Methylmethacrylate Cement for closure of anterior skull base after endoscopic pituitary surgery.& Technical Note. Congress of Neurological Surgeons, New Orleans, 2009
  19. Moliterno J, Boockvar JA.& EGFR activation confers a malignant phenotype to CNS stem cells.& CNS, New Orleans, 2009
  20. Bayene R, Boockvar JA.& Optimization of GBM tumor stem cell harvest and transfection.& Technical Note. Congress of Neurological Surgeons, New Orleans, 2009

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