Publications
Iadecola C, Zhang F, Niwa K, Eckman C, Younkin S, Turner SK, Fischer E, Borchell D, Hsiao KK and Carlson GA: SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci. 2: 157-161, 1999.
Niwa K, Araki E, Morham S, Ross ME and Iadecola C: Cyclooxygenase-2 contributes to functional hyperemia in whisker-barrel cortex. J Neurosci. 20: 763-770, 2000.
Niwa K, Younkin L, Ebeling C, Turner SK, Westaway D, Younkin S, Hsiao Ashe K, Carlson GA and Iadecola C: Aß1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci (USA), 97: 9735-9740, 2000.
Yang G, Huard J, Beitz AJ, Ross ME and Iadecola C: Stellate neurons mediate functional hyperemia in cerebellar molecular layer. J Neurosci. 20: 6968-6973, 2000.
Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E, Morham S and Ross ME: Reduced susceptibility to ischemic brain injury and NMDA-mediated neurotoxicity in cyclooxygenase-2 deficient mice. Proc Natl Acad Sci (USA), 98: 1294-1299, 2001.
Niwa K, Haensel C, Ross ME and Iadecola C: Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation. Circ Res. 88: 600-608, 2001.
Iadecola C: Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci. 5: 347-360, 2004.
Wang G, Anrather J, Huang J, Speth RB, Pickel VM and Iadecola C: NADPH oxidase contributes to angiotensin II signaling in the nucleus tractus solitarius. J Neurosci. 24: 5516-5524, 2004.
Kazama K, Anrather J, Zhou P, Girouard H, Frys K, Milner TA and Iadecola C: Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ Res. 95: 1019-1026, 2004.
Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA and Iadecola C: NADPH oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. J Neurosci. 25: 1769-1777, 2005.
Cho S, Park EM, Febbraio M, Anrather J, Park L, Racchumi G, Silverstein RL and Iadecola C: The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. J Neurosci. 25: 2504-2512, 2005.
Kawano T, Anrather J, Zhou P, Park L, Wang G, Frys KA, Kunz A, Cho S, Orio M and Iadecola C: Prostaglandin E2 EP1 receptors: Downstream effectors of COX-2 neurotoxicity. Nat Med. 12: 225-229, 2006.
Anrather J, Racchumi G and Iadecola C: NF-kB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J Biol Chem. 281: 5657-5667, 2006.
Iadecola C, Goldman SS, Harder DR, Heistad DD, Katusic ZS, Moskowitz MA, Simard JM, Sloan MA, Traystman RJ and Velletri PA: Recommendations of the National Heart, Lung, and Blood Institute working group on cerebrovascular biology and disease. Stroke, 37: 1578-1581, 2006.
Girouard H, Park L, Anrather J, Zhou P and Iadecola C: Cerebrovascular nitrosative stress mediates neurovascular and endothelial dysfunction induced by angiotensin II. Arteriosclerosis Thromb Vasc Biol. 27: 303-309, 2007.
Iadecola C: Astrocytes take center stage in salt sensing. Neuron, 54: 3-5, 2007.
Kunz A, Park L, Abe T, Gallo EF, Anrather J, Zhou P and Iadecola C: Neurovascular protection by ischemic tolerance: role of nitric oxide and reactive oxygen species. J Neurosci. 27: 7083-7093, 2007.
Iadecola C and Nedergaard M: Glial regulation of the cerebral microvasculature. Nat Neurosci. 10: 1369-1376, 2007.
Kunz A, Abe T, Hochrainer K, Shimamura M, Anrather J, Racchumi G, Zhou P and Iadecola C: Nuclear factor-kb activation and post-ischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion. J Neurosci. 28: 1649-1658, 2008.
Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS and Iadecola C: Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proc Natl Acad Sci (USA), 105: 1347-1352, 2008.
Park L, Gallo EF, Anrather J, Wang G, Norris EH, Paul J, Strickland S and Iadecola C: Key role of tissue plasminogen activator in neurovascular coupling. Proc Natl Acad Sci (USA), 105: 1073-1078, 2008.
Girouard, H., Wang, G., Gallo, E.F., Anrather, J., Zhou, Pickel, V. M., Iadecola, C.: NMDA receptor activation increases free radical production through nitric oxide and NOX2. J. Neurosci, 29:2545-2552, 2009.
Capone, C., Anrather, J., Milner, T.M., And Iadecola, C.: Estrous cycle dependent neurovascular dysfunction induced by angiotensin II in the mouse neocortex. Hypertension, 54:302-307, 2009.
Iadecola, C.: Bleeding in the brain: Killer waves of depolarization in subarachnoid bleed. Nat Med. 15:1131-1132, 2009.
Yin, F, Banerjee, R., Thomas, B., Zhou, P., Qian, L., Jia, T., Ma, X., Ma, Y., Iadecola, C., Beal, M.F., Nathan, C and Ding, A: Exaggerated Inflammation and Brain Dysfunction in Progranulin- Deficient Mice. J. Exp. Med., 207:117-128, 2010.
Capone, C., Faraco, G., Anrather, J., Zhou, P., and Iadecola, C.: COX-1-derived prostaglandin E2 and EP1 receptors are required for the cerebrovascular dysfunction induced by angiotensin II. Hypertension, 55:911-917, 2010
Abe, T., Shimamura, M., Jackman, K., Kurinami, I., Anrather, J., Zhou, P., and Iadecola, C.: Key role of CD36 in Toll-like receptor 2 signaling in cerebral ischemia. Stroke, 41:898-904, 2010
Iadecola, C.: The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropath, 120:287-296, 2010
Moskowitz, M.A., Lo, E. and Iadecola C.: The Science of Stroke: Mechanisms in Search of Treatments. Neuron, 67: 181-198, 2010
Coleman C., Wang, G., Park, L., Anrather, J., Delagrammatikas, G., Chan, J., Zhou, J., Iadecola, C., and Pickel V.: Chronic intermittent hypoxia induces NMDA receptor-dependent plasticity and suppresses nitric oxide signaling in the mouse hypothalamic paraventricular nucleus. J. Neurosci., in press
