Protein-protein interactions form the basis of a majority of biological processes. A vital step in studying protein-protein recognition is the visualization of the interactions at atomic resolution. This is often the most effective means that can provide a satisfactory understanding of how certain interactions lead to or result from specific biological responses.

Of particular interest to our laboratory are protein recognition processes involved in the post-receptor signaling by the tumor necrosis factor receptor (TNFR) superfamily. This family of receptors can induce a diverse set of cellular responses including cell survival, cell proliferation and differentiation, and apoptosis. TNFRs play important roles in many biological processes, including cellular homeostasis, regulation of immune functions, inflammatory and acute phases responses, and fetal development.

While many proteins have been identified in the TNFR signaling pathway, the molecular mechanisms by which they carry out their tasks are still poorly understood. We intend to use a combination of X-ray crystallography and biophysical methods to elucidate the structural basis of this signal transduction.

For furthur information see: Dr. Wu's Lab