Publications
1. Liou, H.-C. and Wu, H.-K. (1983). Cytogenetics of Rice Trisomics. Master thesis. National Taiwan University.
2. Gunaratne, P. H., Mansukhani, A., Lipari, S. E., Liou, H.-C., Martindale, D. W. and Goldberg, M. L. (1986). Molecular cloning, germ-line transformation, and transcriptional analysis of the zeste locus of Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 83, 701-705.
3. Polla, B. S., Ohara, J., Paul, W. E., Nabavi, N., Myer A., Liou, H.-C., Shen, F.-W., Gillis, S., Bonventre, J. V. and Glimcher, L. H. (1988). Differential induction of class II gene expression in murine pre-B-cell lines by B-Cell Stimulatory Factor-1 and by antibodies to B-cell surface antigens. J. Mol. Cell Immunol. 3, 363-373.
4. Liou, H.-C., Polla, B. S., Aragnol, D., Leserman, L.D., Griffith, I. J. and Glimcher, L. H. (1988). A tissue-specific DNase I hypersensitive site in a class II A-alpha gene is under trans-regulatory control. Proc. Natl. Acad. Sci. USA 85, 2738-2742.
5. Liou, H.-C., Boothby, M. and Glimcher, L. H. (1988). Distinct cloned class II MHC DNA binding proteins recognize the X box transcription element. Science 242, 69-71.
6. Boothby, M., Gravallese, E., Liou, H.-C. and Glimcher, L. H. (1988). A DNA-binding protein regulated by IL-4 and by differentiation in B cells. Science 242, 1559-1562.
7. Boothby, M., Liou, H.-C. and Glimcher, L.H. (1989). Differences in DNA sequence specificity among MHC class II X box binding proteins. J. Immunology 142, 1005-1014.
8. Liou, H.-C. (1989). Transcriptional regulation of MHC class II gene expression in murine B cells. Ph.D. Thesis. Harvard University.
9. Fontaine, B., Hanson, M.P., Liou, H.-C., Glimcher, L.H., Rouleau, G.A. and Gusella, J.F. (1990). hXBP-1 (human X-box binding protein) displays a Ban I polymorphism on human chromosome 5. Nucl. Acid Res. 18, 5578.
10. Liou, H.-C., Boothby, M.R., Finn, P.W., Davidon, R., Nabavi, N., Zeleznik-Le, N.J., Ting, P.-Y. and Glimcher, L.H. (1990). A new member of the leucine zipper class of proteins binds to the HLA DR-alphapromoter. Science 247, 1581-1584.
11. Ivashkiv, L.B., Liou, H.-C., Kara, C.J., Lamph, W.W., Verma, I.M. and Glimcher, L.H. (1990). mXBP and c-Jun form a complex which binds to the cyclic-AMP, but not to the TPA response element. Mol. Cell. Biol. 10(4), 1609-1621
12. Kara, C.J., Liou, H.-C., Ivashkiv, L.B. and Glimcher, L.H. (1990). A cDNA for a human CRE-binding protein which is distinct from CREB and expressed preferentially in brain. Mol. Cell. Biol. 10(4), 1347-1357.
13. Liou, H.-C., Ivashkiv, L.B., Kara, C.J. and Glimcher, L.H. (1990). Transcriptional regulation of MHC class II gene expression: Are MHC class II genes coordinately regulated? in : Transgenic mice and mutants in MHC researches. I.K. Egorov and C.S. David (Eds). Springer-Verlag, Heidelberg, Germany. pp: 133-142.
14. Boothby, M., Liou, H.-C., Finn, P.W., Gravallese, E. and Glimcher, L.H. (1990). Control of transcription at the murine A-alpha locus. Immunologic Research 9, 77-92. MHC Class II Genes and Molecules, Symposium (Part II). S. Karger AG, Basel.
15. Liou, H.-C., Eddy. R., Shows, T., Lisowska-Grospierre, B., Griscelli, C., Mannhalter, J., Doyle, C. and Glimcher, L.H. (1991). An HLA-DR-alpha promoter DNA-binding protein is deficient in a class II negative mutant cell line and maps to human chromosome 22 and 5. Immonogenetics 34, 286-292.
16. Ono, S.J., Liou, H.-C., Davidon, R., Strominger, J.L. and Glimcher, L.H.(1991). Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos. Proc. Natl. Acad. Sci. USA 88,4309-12.
17. Nolan, G.P., Ghosh, S., Liou, H.-C., Tempst, P. & Baltimore, D. (1991). DNA binding and IkB inhibition of the cloned p65 subunit of NF-kB, a rel-related polypeptide. Cell 64, 961-969.
18. Davis, N., Ghosh, S., Simmons, D. L., Tempst, P., Liou, H.-C., Baltimore, D. and Bose, H.R.Jr. (1991). Rel-associated pp40: An inhibitor of the rel family of transcription factors. Science 253, 1268-1271.
19. Liou, H.-C., Nolan, G. P., Ghosh, S., Fujita, T. and Baltimore, D. (1992). The NF-kB p50 precursor, p105, contains an internal IkB-like inhibitor that preferentially inhibits p50. EMBO J. 11, 3003-3009.
20. Liou, H.-C. and Baltimore, D. (1993). Regulation of the NF-kB/rel transcription factor and IkB inhibitor system. Current Opinion in Cell Biology 5, 477-487.
21. Nolan, G.P., Fujita, T., Bhatia, K., Huppi, C., Liou, H.-C., Scott, M. and Baltimore, D. (1993). The bcl-3 proto-oncogene encodes a nuclear resident IB-like molecule that preferentially interacts with NF-kB p50 and p52 in a phosphorylation-dependent manner. Mol. Cell. Biol. 13, 3557-3566.
22. Scott, M. L., Fujita, T., Liou, H.-C., Nolan, G. and Baltimore, D. (1993). The p65 subunit of NF-kB regulates IkB by two distinct mechanisms. Genes & Dev. 7, 1266-1276.
23. Fujita, T., Nolan, G.P., Liou, H.-C., Scott, M.L. and Baltimore, D. (1993). The candidate proto-oncogene bcl-3 encodes a transcriptional co-activator that activates NF-kB p50 homodimers. Genes & Dev. 7, 1354-1363.
24. Ponath,P.D., Fass, D., Liou, H.-C., Glimcher, L.H. and J.L. Strominger (1993). The regulatory gene, hXBP-1, and its target, HLA-DRA, utilize both common and distinct regulatory elements and protein complexes. J. Biol. Chem. 268 (23):17074-82.
25. Liou, H.-C., Sha, W. C., Scott, M. L. and Baltimore, D. (1994). Sequential induction of NF-kB/Rel family proteins during B cell terminal differentiation. Mol. Cell. Biol. 14 (8), 5349-5359.
26. Sha, W.C., Liou, H.-C., Tuomanen, E.I. and Baltimore, D. (1995). Targeted disruption of the p50 subunit of NF-B leads to multifocal defects in immune responses. Cell 80(2), 321-330.
27. Lee, S.Y., Lee, S. Y., Kandala, G., Liou, M.-L., Liou, H.-C., and Choi, Y. (1996). CD30-TRAF interaction: the binding specificity and the NF-kB activation. Proc. Natl. Acad. Sci. USA 93, 9699-9703.
28. Andjelic, S. and Liou, H.-C. (1998). Activation-induced B lymphocyte apoptosis is mediated via a protease from the caspase family. Eur. J. Immunol. 28, 570-581.
29. Cerutti, A., Schaffer, A., Shah, S., Zan, H., Liou, H.-C., Goodwin, R.G., and Casali, P. (1998). CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non antigen-selected human B cells. Immunity 9, 1-20.
30. Tumang, J., Owyang, A., Andjelic, S., Jin, Z., Hardy, R.R., Liou, M.-L. and Liou, H.-C. (1998). C-Rel is essential for B lymphocyte survival, cell cycle progression, and terminal differentiation. Eur. J. Immunol. 28, 4299-4312.
31. Liou, H.-C., Jin, Z., Tumang, J., Andjelic, S., Smith, K.A., and Liou, M.-L. (1999). C-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. International Immunol. 11(3), 361-371.
32. Liou, M.-L. and Liou, H.-C. (1999). The ubiquitin-homology protein, DAP-1, associates with TNF receptor (p60) death domain and induces apoptosis. J. Biol. Chem. 274, 10145-10153.
33. Donova, C., Mark, D.A. He, H.Z., Liou, H.-C., Kobzik, L., Wang, Y., De Sanctis, G.T., Perkins, D.L. and Finn, P.W. (1999). NF-kB/Rel transcription factors: c-Rel promotes airway hyperresponsiveness and allergic pulmonary inflammation. J. Immunol. 163, 6827-6833.
34. Furman, R.R., Asgary, Z., Mascarenhas, J.O., Liou, H.-C. , and Schattner, E.J. (2000). Modulation of NF-kB activity and apoptosis in chronic lymphocytic leukemia B cells. J. Immunol. 164, 2200-2206.
35. Park, Y.C., Ye, Hsia, C. Segal, D., Rich, R., Liou, H.-C., Myszka, D.G., and Wu, H. (2000). Structural analysis for the coupling of TRAF2 signaling through TRADD. Cell, 101, 777-787.
36. Andjelic, S. Suzuki, H., Kadowaki, T., Koyasu, S., and Liou, H.-C. (2000). PI-3 kinase is at divergence of CD40-mediated proliferation and survival pathways. J. Immunol. 165, 3860-3867.
37. Cariappa, A., Liou, H.-C., Horwitz, B.H., and Pillai, S. (2000). NF-kB is required for the development of marginal zone B lymphocytes. J. Exp Med. 192, 1175-1182.
38. Sanjabi, S., Hoffman, A., Liou, H.-C., Baltimore, D. and Smale, S.T. (2000). Selective requirement for c-Rel during interleukin-12 p40 gene induction in macrophages. Proc. Natl. Acad. Sci. USA 97, 12705-10.
39. Weinmann, A.S., Mitchell, D.M., Sanjabi, S., Studley, M.N., Hoffmann, A., Liou, H.-C., and Smale, S.T. (2001). Nucleosome remodeling at a proinflammatory cytokine promoter is a TLR-dependent, Rel-independent event. Nature Immunol. 2, 51-57.
40. Owyang, A., Tumang, J.R., Schram, B.R., Hsia, C.Y., Behrens, T.W., Rothstein, T.L., and Liou, H.-C. (2001). C-Rel is required for the protection of B cells from antigen receptor mediated but not Fas mediated apoptosis. J. Immunol., 167, 4948-4956.
41. Bernal, A., Pastore, R.D., Asgary, Z., Keller, S., Cessarman, E., Liou, H.-C., and Schattner, E.J. (2001). Survival of leukemic B cells promoted by engagement of the antigen receptor. Blood 98, 3050-3057.
42. Mason, N., Aliberti, D.J., Caamano, J.C., Liou, H.-C., Hunter, C.A. (2002). Identification of c-Rel dependent and independent pathways of IL-12 production during infectious and inflammatory stimuli. J. Immunol. 168, 2590-2594.
43. Hsia, C.Y., Cheng, S., Owyang, A.M., Dowdy, S., and Liou, H.-C. (2002). C-Rel regulation of the cell cycle in primary mouse B lymphocytes. International Immunol. 14(8), 905-916.
44. Pizzi, M. Goffi, F., Boroni, F., Benarese, M., Perkins, S.E., Liou, H.-C., and Spano, P.F. (2002). Opposite roles for NF-kB/Rel p65 and c-Rel transcription factors in the control of neuron survival. J. Biol. Chem, 277(23), 20717-20723.
45. Hua, Y., Thomas, D., Ding, R., Li, B., Boffa, D.J., Muthukumar, T., Sharma, V.K., Lagman, M., Luo, G.-X., Liou, H.-C., Hancock, W.W., and Suthanthiran, M. (2002). Enforced c-Rel deficiency prolongs survival of islet allografts. Transplantation 74(3), 291-298.
46. Hilliard, B.A., Xu, L., Labhamedi-Cherradi, S., Mason, N., Liou., H.-C., Hunter, C., and Chen, Y.H. (2002). Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. J. Clin. Inv. 110, 843-850.
47. Artis, D., Shapira, S., Mason, N., Speirs, K.M., Goldschmidt, M., Caamano, J., Liou, H.-C., Hunter, C. A., and Scott, P. (2002). Differential requirement for NF-kB family members in control of helminth infection and intestinal inflammation. J. Immunol. 169, 4481-4487.
48. Tumang, J.R., Hsia, C.Y., Tian, W., Bromberg, J.F., and Liou, H.-C. (2002). IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2. Cell. Immunol., 217, 47-57.
49. Liou, H.-C. (2002). Regulation of host immunity by NF-kB and IkB gene family. J. Biochem. Mol. Biol. 35, 537-546.
50. Finn, P., He, H., Ma, C., Mueller, T., Liou, H.-C., Boothby, M., Stone, J. R., and Perkins, D.L. (2002). Molecular profiling of the role of NF-kB family of transcription factors during alloimmunity. J. Leuk. Biol., 72, 1054-1062.
51. Boffa, D., Feng, B., Sharma, V., Dematteo, R., Suthanthiran, M., Nunez, R., and Liou, H.-C. (2003). Selective loss of c-Rel compromises dendritic cell activation of T lymphocytes. Cell. Immunol. 222, 105-115.
52. Hatada, E., Do, R.K., Orlofsky, A., Liou, H.-C., Prystowski, M., MacLennan, I., Caamano, J., and Chen-Kiang, S. (2003). NF-kB1 p50 is required for Blys attenuation of apoptosis but dispensable for processing NF-kB2 p100 to p52 in quiescent mature B cells. J. Immunol. 171, 761-768.
53. Liou, H.-C., Hsia, C.Y., (2003). Distinctions between c-Rel and other NF-kB proteins in immunity and disease. BioEssays, 25, 767-780.
54. Cheng, S., Hsia, C.Y., G. Leone, and Liou, H.-C. (2003). Cyclin E and Bcl-xL cooperatively induce cell cycle progression in c-Rel-/- B cells. Oncogene 22, 8472-8486.
55. Lamhamedi-Cherradi, S., Zheng, S., Hilliard, B.A., Xu, L., Sun, J., Alsheadat, S., Liou, H.-C., Chen, Y.H. (2003). Transcriptional regulation of type I diabetes by NF-kB. J. Immunol. 171,4886-4892.
56. Feng, B., Cheng, S., Pear, W. S, Liou, H.-C. (2004). NF-kB inhibitor blocks B cell development at two checkpoints. Medical Immunology 3:1.
57. Mason, N.J., Liou, H.-C., and Hunter, C. A. (2004). T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii. J. Immunol. 172, 3704-11.
58. Levenson, J.M., Choi, S., Lee, S.-Y., Cao, Y.A., Ahn, H.-J., Worley, K.C., Pizzi, M., Liou, H.-C., Sweatt, J.D. (2004). A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-Rel. J. Neuroscience 24(16):3933-3943.
59. Nunez, R., Fraefel, C., Suter, M, Liou, H.-C., Ackerman, M. (2004). Assessment of a cellular vaccination approach consisting of crawling dendritic cells (CDC) transduced with HSV-1-delta-pac vector. Immunol. Res. 29(3):
60. Huang, X, Liberto, M.D., Cunningham, A.F., Kang, L., Cheng, S., Ely, S., Liou, H.-C., MacLennan, I.C.M., Cheng-Kiang, S. (2004). Homeostatic cell cycle control by Blys: introduction of cell cycle entry but not G1/S transition in opposition to p18-INK4c and p27-Kip1. Proc. Natl. Acad. Sci. 101(51): 17789-17794.
61. Feng, B., Cheng, S., Hsia, C. King, L., Monroe, J., Liou, H.-C. (2004). NF-kB inducible Bcl-X and cyclin E promote immature B cell survival and proliferation. Cell Immunol., 232, 9-20.
62. Pizzi, M. Sarnico, I., Boroni, F., Benarese, M., Steimberg, N., Mazzoleni, G., Dietz, G.P.H., Bahr, M., Cheng, S., Liou, H.-C., Spano, P.F. (2005). NF-kB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid b-peptide toxicitiy. Cell Death and Diff, 12, 761-772.
63. Tian, W., Nunez, R., Cheng, S., Ding, Y., Tumang, J., Lyddane, C., Roman, C., and Liou, H.-C. (2005). C-type lectin OCILRP2 and its ligand NKRP1f costimulate T cell proliferation and IL-2 production. Cell Immunol., 234, 39-53.
64. Corn, R.A., Hunter, C., Liou, H.-C., Siebenlist, U., and Boothby, M.R. (2005). Opposing roles for RelB and Bcl-3 in regulation of T-bet, GATA-3, and T helper effector differentiation. J. Immunol.., 175, 2102-2110.
65. Tian, W., Feng, B., and Liou, H.-C. (2005). Silencing OCILRP2 leads to intrinsic defects in T cells in response to antigenic stimulation. Cell Immunol., 235, 72-84.
66. Banerjee, D., Liou, H.-C., Sen, R. (2005). C-Rel-dependent priming of naïve T cells by inflammatory cytokines. Immunity, 23, 445-58.
67. Liou, H.-C., Feng, B., Tian, W., Cheng, S., Hsia, C.Y. (2006). NF-kB and immune cell effector functions. Chapter 8, NF-kB Transcription Factor Family (Editor: Hsiou-Chi Liou; Publisher: Landes Biosciences, Georgetown, Texas; Springer, New York, NY)
68. Tato, C.M., Mason, N., Artis, D. Shapira, S. Caamano, J.C., Bream, J.H., Liou, H.-C., Hunter, C.A. (2006). Opposing roles of NF-kB family members in the regulation of NK cell proliferation and production of IFN-g. Int. Immunol. 18, 505-13.
69. ORiordan, KJ, Huang, I-C, Spano, PF, Boroni, F. Desai, P, Ahn, HJ, Liou, H.-C., Pizzi, M, Sweatt, JD, Levenson, JM (2006). Regulation of NF-kB in the hippocampus by group I metabotropic glutamate receptors. J. Neuroscience 26, 4870-9.
70. Inta, I., Paxian, S, Zhang, W, Pizzi, M, Muhammad, S, Herrmann, O, Liou, H.-C., Schmid, RM, Schwaninger, M. (2006). Bim and Noxa are candidates to mediate the deleterious effect of the NF-kB subunit RelA in cerebral ischemia. J. Neuroscience, 26, 12896-903.
71. Carmody, R.J., Ruan Q, Liou, H.-C., and Chen, Y. H. (2006). Essential roles of c-Rel in Toll-like receptor-induced IL-23 p19 gene expression in dendritic cells. J. Immunol., 178, 186-191.
72. Judge, AR, Koncarevic, A., Hunter, B, Liou, H.-C., Jackman, RW., Kandarian, SC (2007) A role for IkB-alpha, but not c-Rel, in skeletal muscle atrophy . Manuscript submitted.
73. Cheng, S., Hsia, C.Y., Feng, B., Liou, M.-L., Fang, X., Pandolfi, P.P., and Liou, H.-C. (2007). A coordinated balance of antigen receptor-inducible PTEN and PI3K activities supports negative selection of immature B cells. Manuscript submitted.
74. Yang, Y., Liou, H.-C., Sun, X.-H. (2007). Id1 potentiates NF-kB activation upon TCR signaling. Manuscript submitted.
75. Cheng, S., Tian, W., Feng, B., Liou, M.-L., Trotman, L. Pandolfi, P.P., Liou, H.-C. (2007). C-Rel blockade attenuates hyper-proliferation and lymphoma derived from mutation in the Pten tumor suppressor. Manuscript in preparation.
76. Hsia, C. Y., Owyang, A., Hsu, J.J., Tian, W., Xiang, J. and Liou, H.-C. (2007). Bioinformatics analysis reveals distinct c-Rel-mediated gene expression profiles in response to BCR and CD40 signals. Manuscript in preparation.
77. Tian, W. Liou, H.-C. (2007). RNAi-mediated c-Rel silencing leads to growth arrest and apoptosis of B cell lymphoma and suppresses lymphocyte response to antigen stimulation in vivo. Manuscript in preparation.
PATENTS, LICENSE & INVENTION:
1. C-Rel knockout mice for evaluating therapeutic efficacy, toxicity, and dosage in immunodeficient host
2. Compositions and methods for targeting c-Rel
