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38. Sanjabi, S., Hoffman, A., Liou, H.-C., Baltimore, D. and Smale, S.T. (2000). Selective requirement for c-Rel during interleukin-12 p40 gene induction in macrophages. Proc. Natl. Acad. Sci. USA 97, 12705-10.
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45. Hua, Y., Thomas, D., Ding, R., Li, B., Boffa, D.J., Muthukumar, T., Sharma, V.K., Lagman, M., Luo, G.-X., Liou, H.-C., Hancock, W.W., and Suthanthiran, M. (2002). Enforced c-Rel deficiency prolongs survival of islet allografts. Transplantation 74(3), 291-298.
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48. Tumang, J.R., Hsia, C.Y., Tian, W., Bromberg, J.F., and Liou, H.-C. (2002). IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2. Cell. Immunol., 217, 47-57.
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55. Lamhamedi-Cherradi, S., Zheng, S., Hilliard, B.A., Xu, L., Sun, J., Alsheadat, S., Liou, H.-C., Chen, Y.H. (2003). Transcriptional regulation of type I diabetes by NF-kB. J. Immunol. 171,4886-4892.
56. Feng, B., Cheng, S., Pear, W. S, Liou, H.-C. (2004). NF-kB inhibitor blocks B cell development at two checkpoints. Medical Immunology 3:1.
57. Mason, N.J., Liou, H.-C., and Hunter, C. A. (2004). T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondii. J. Immunol. 172, 3704-11.
58. Levenson, J.M., Choi, S., Lee, S.-Y., Cao, Y.A., Ahn, H.-J., Worley, K.C., Pizzi, M., Liou, H.-C., Sweatt, J.D. (2004). A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-Rel. J. Neuroscience 24(16):3933-3943.
59. Nunez, R., Fraefel, C., Suter, M, Liou, H.-C., Ackerman, M. (2004). Assessment of a cellular vaccination approach consisting of crawling dendritic cells (CDC) transduced with HSV-1-delta-pac vector. Immunol. Res. 29(3):
60. Huang, X, Liberto, M.D., Cunningham, A.F., Kang, L., Cheng, S., Ely, S., Liou, H.-C., MacLennan, I.C.M., Cheng-Kiang, S. (2004). Homeostatic cell cycle control by Blys: introduction of cell cycle entry but not G1/S transition in opposition to p18-INK4c and p27-Kip1. Proc. Natl. Acad. Sci. 101(51): 17789-17794.
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62. Pizzi, M. Sarnico, I., Boroni, F., Benarese, M., Steimberg, N., Mazzoleni, G., Dietz, G.P.H., Bahr, M., Cheng, S., Liou, H.-C., Spano, P.F. (2005). NF-kB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid b-peptide toxicitiy. Cell Death and Diff, 12, 761-772.
63. Tian, W., Nunez, R., Cheng, S., Ding, Y., Tumang, J., Lyddane, C., Roman, C., and Liou, H.-C. (2005). C-type lectin OCILRP2 and its ligand NKRP1f costimulate T cell proliferation and IL-2 production. Cell Immunol., 234, 39-53.
64. Corn, R.A., Hunter, C., Liou, H.-C., Siebenlist, U., and Boothby, M.R. (2005). Opposing roles for RelB and Bcl-3 in regulation of T-bet, GATA-3, and T helper effector differentiation. J. Immunol.., 175, 2102-2110.
65. Tian, W., Feng, B., and Liou, H.-C. (2005). Silencing OCILRP2 leads to intrinsic defects in T cells in response to antigenic stimulation. Cell Immunol., 235, 72-84.
66. Banerjee, D., Liou, H.-C., Sen, R. (2005). C-Rel-dependent priming of na•ve T cells by inflammatory cytokines. Immunity, 23, 445-58.
67. Liou, H.-C., Feng, B., Tian, W., Cheng, S., Hsia, C.Y. (2006). NF-kB and immune cell effector functions. Chapter 8, NF-kB Transcription Factor Family (Editor: Hsiou-Chi Liou; Publisher: Landes Biosciences, Georgetown, Texas; Springer, New York, NY)
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69. O?Riordan, KJ, Huang, I-C, Spano, PF, Boroni, F. Desai, P, Ahn, HJ, Liou, H.-C., Pizzi, M, Sweatt, JD, Levenson, JM (2006). Regulation of NF-kB in the hippocampus by group I metabotropic glutamate receptors. J. Neuroscience 26, 4870-9.
70. Inta, I., Paxian, S, Zhang, W, Pizzi, M, Muhammad, S, Herrmann, O, Liou, H.-C., Schmid, RM, Schwaninger, M. (2006). Bim and Noxa are candidates to mediate the deleterious effect of the NF-kB subunit RelA in cerebral ischemia. J. Neuroscience, 26, 12896-903.
71. Carmody, R.J., Ruan Q, Liou, H.-C., and Chen, Y. H. (2006). Essential roles of c-Rel in Toll-like receptor-induced IL-23 p19 gene expression in dendritic cells. J. Immunol., 178, 186-191.
72. Judge, AR, Koncarevic, A., Hunter, B, Liou, H.-C., Jackman, RW., Kandarian, SC (2007) A role for IkB-alpha, but not c-Rel, in skeletal muscle atrophy . Manuscript submitted.
73. Cheng, S., Hsia, C.Y., Feng, B., Liou, M.-L., Fang, X., Pandolfi, P.P., and Liou, H.-C. (2007). A coordinated balance of antigen receptor-inducible PTEN and PI3K activities supports negative selection of immature B cells. Manuscript submitted.
74. Yang, Y., Liou, H.-C., Sun, X.-H. (2007). Id1 potentiates NF-kB activation upon TCR signaling. Manuscript submitted.
75. Cheng, S., Tian, W., Feng, B., Liou, M.-L., Trotman, L. Pandolfi, P.P., Liou, H.-C. (2007). C-Rel blockade attenuates hyper-proliferation and lymphoma derived from mutation in the Pten tumor suppressor. Manuscript in preparation.
76. Hsia, C. Y., Owyang, A., Hsu, J.J., Tian, W., Xiang, J. and Liou, H.-C. (2007). Bioinformatics analysis reveals distinct c-Rel-mediated gene expression profiles in response to BCR and CD40 signals. Manuscript in preparation.
77. Tian, W. Liou, H.-C. (2007). RNAi-mediated c-Rel silencing leads to growth arrest and apoptosis of B cell lymphoma and suppresses lymphocyte response to antigen stimulation in vivo. Manuscript in preparation.

PATENTS, LICENSE & INVENTION:

1. C-Rel knockout mice for evaluating therapeutic efficacy, toxicity, and dosage in immunodeficient host

2. Compositions and methods for targeting c-Rel