Publications
Publications 2004-2009
Edited books or volumes
Handbook of Neurochemistry and Molecular Biology. 3rd Edition Volume 5. 2007. Brain energetics Integration of molecular and cellular processes. Edited by Gary E. Gibson and Gerald Dienel. (Volume editor A. Lajtha). Springer Publishing 923 pages. The volume has 33 chapters from 87 contributors.
Special volume of Neurochemical Research 2007. 32(4/5) that is dedicated to Dr. John Blass. It includes 37 contributions and is 413 pages. The volume includes contributions from both physicians and scientists. The volume is 418 pages long. It includes 37 manuscripts co-authored by 144 different individuals from around the world. It includes contributions from twelve different countries (Italy, Hungary, Australia, Japan, Korea, Denmark, Norway, Germany, Portugal, Poland, England, Russia), five different medical schools within NY, twelve different states. The contributors include two division directors at NIH and a Nobel Prize winner. Each paper was reviewed by 3-5 experts in the area and revised accordingly. Some papers were revised three times before the necessary quality was achieved.
Mitochondria and Oxidative Stress. 2008. Edited by Gary E. Gibson, Rajiv R. Ratan, M. Flint Beal. Annals of the New York Academy of Sciences 1147. 414 pages. The book resulted from a meeting we organized. This Conference covered basic, clinical and translational (bench to bedside) research related to mitochondrial function and its roles in neurodegenerative age related diseases and their treatment. The number of abstracts was among the largest for a NY Academy of Sciences meeting. The conference was attended by 288 people from 25 countries, and registration had to be closed for lack of space. Thirty-five percent of attendees were from countries other than the U.S. There were 44 speakers of which many were the "world leader" on their subject. There were also 124 high quality poster presentations (a very large number for a meeting of this size) from many countries around the world.
Research Papers
Huang HM, Fowler C, Zhang H, Gibson, GE. 2004. Mitochondrial Heterogeneity Within and Between Different Cell Types. Neurochemical Research 29:651-658.
Klivenyi, P. Starkov, A. A., Calingasan, N. Y., Gardian, G., Browne S. E., Yang, L., Bubber, P., Gibson, G. E., Patel, M. S., and Beal, M. F. 2004. Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3-nitropropionic acid neurotoxicity. J Neurochem. 88:1352-60.
Bubber P., Tang J., Haroutunian V., Xu H, Davis KL, Blass JP, Gibson GE. 2004. Mitochondrial Enzymes in Schizophrenia. Journal of Molecular Neuroscience 24:315-321.
Bubber, P, Ke ZJ, and Gibson GE. 2004. Tricarboxylic acid cycle enzymes following thiamine deficiency. Neurochemistry International 45:1021-1028.
Huang HM, Zhang H, Ou HC, Chen HL Gibson GE. 2004. α-Keto-ß-methyl-n-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca2 stores. Free Radical Biology and Medicine. 37:1779-1789.
Huang HM, Fowler C, Xu H, Zhang H., Gibson GE. 2005. Mitochondrial function in fibroblasts with aging in culture and/or Alzheimer's disease. Neurobiology of Aging 29:651-658.
Jeitner TM, Xu, H. Gibson, GE. 2005. Inhibition of α-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine. J. Neurochem 92:302-310.
Shi Q, Chen HL, Xu H, and Gibson GE. 2005. Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity. Journal of Biological Chemistry 280:10888-10896.
Bubber, P., .Haroutunian, V., Fisch, G., Blass. J.P., Gibson, G.E. 2005. Mitochondrial abnormalities in Alzheimer brain: mechanistic implications Annals of Neurology 57:695-703.
Ke ZJ, Calingasan NY, DeGiorgio LA, Volpe BT, Gibson GE. 2005. CD40-CD40L Interactions promote Neuronal Death in a Model of Neurodegeneration Due to Mild Impairment of Oxidative Metabolism. Neurochemistry International 47:204-215.
Krasnikov, B.F., Kim, S.Y., McConoughey, S.J., Ryu, H., Xu, H., Stavrovskaya, I., Iismaa, S., Mearns, B., Ratan R.R., Blass, J.P., Gibson G.E., Cooper, A.J.L. (2005) Transglutaminase Activity is Present in Highly Purified Non-Synaptosomal Mouse Brain and Liver Mitochondria. Biochemistry 44(21):7830-7843.
Ke ZJ, Calingasan NY, Karuppagounder, S.S., DeGiorgio LA, Volpe BT, Gibson GE. 2005. CD40L Deletion Delays Neuronal Death in a Model of Neurodegeneration Due to Mild Impairment of Oxidative Metabolism. J. Neuroimmunology. 164:85-92.
Huang, H.M., Chen H.L., Xu, H. and Gibson, G.E. 2005. Modification of endoplasmic reticulum Ca2 stores by select oxidants produces changes reminiscent of those in cells from patients with Alzheimer's disease. Free Radical Biol. Med. 39:979-989.
Bunik, V.I., Denton, T.T., Xu, H., Thompson, C.M., Cooper, A.J.L., Gibson G.E. 2005. Phosphonate analogues of α-ketoglutarate inhibit the activity of the α-ketoglutarate dehydrogenase complex isolated from brain and in cultured cells. Biochemistry 44:10552-10561.
Waagepetersen H.S., Hansen G.H., Fenger K.,Lindsay J.G., Gibson G.E., Schousboe A. 2005. Cellular mitochondrial heterogeneity in cultured astrocytes as demonstrated by immunogold labeling of α-ketoglutarate dehydrogenase. Glia 52:225-231.
Kim SY, Marekov L., Bubber P., Browne SE, Stavrovskaya I. Lee J., Steinert PM, Blass JP, Beal MF, Gibson GE, and Cooper AJL. 2005. Mitochondrial aconitase is a transglutaminase 2 substrate: transglutamination is a probable mechanism contributing to high-molecular-weight aggregates of aconitase and loss of aconitase activity in Huntington disease brain. Neurochemical Research. 30:1245-1255.
Murphy E.J., Huang H-M., Cowburn R.F., Lannfelt L., Gibson, GE. 2006. Phospholipid mass is increased in fibroblasts bearing the Swedish amyloid precursor mutation. Brain Research Bulletin. 69:79-85.
Santos, S.S., Gibson, G.E., Cooper, AJ.L, Denton, T.T., Thompson, C.M., Bunik, V.I., Alves, P.M. and Sonnewald, U. 2006. Inhibitors of -Ketoglutarate Dehydrogenase Complex Alter [1-13C]Glucose and [U-13C]Glutamate Metabolism in Cerebellar Granule Neurons. Journal of Neuroscience Research. 83:450-458.
Ke, Z, Bowen, W.M., Gibson GE. 2006 Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism. Neurochemistry International 49:548-556.
Zhang, L.; Cooper, A. J. L.; Krasnikov, B. F.; Xu, H.; Bubber, P.; Pinto, J. T.; Gibson, G. E.; Hanigan, M. H. 2006. Cisplatin-Induced Toxicity Is Associated with Platinum Deposition in Mouse Kidney Mitochondria in Vivo and with Selective Inactivation of the α-Ketoglutarate Dehydrogenase Complex in LLC-PK1 Cells. Biochemistry 45:8959-8971
Karuppagounder, SS, Shi, Q., Xu, H., Gibson GE. 2007. Changes in Inflammatory Processes Associated With Selective Vulnerability Following Mild Impairment of Oxidative Metabolism. Neurobiology of Disease 26:353-362.
Shi, Q., Karuppagounder, S.S., Xu, H., Pechman, D., Chen, H-L., Gibson, G.E. 2007. Responses of the mitochondrial alpha-ketoglutarate dehydrogenase complex to thiamine deficiency may underlie regional selective vulnerability. Neurochemistry International 50:921-931.
Shi, Q., Xu, H., Kleinman, W.A., Gibson, G.E. 2008. Novel functions of the α-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. Biochim Biophys Acta. Molecular Basis of Disease. 1782:229-238.
Karuppagounder, S.S., Xu, H., Shi, Q., Chen, L.H., Pedrini, S., Pechman, D.P., Baker, H.A., Beal, M.F., Gandy, S.E., Gibson, G.E. 2008. Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiology of Aging 1558-1497 (Electronic)
Calingasan, N.Y., Ho, D.J, Wille, E.J., Campagna, M.V., Ruan, J., Dumont, M., Yang, L. Shi, Q., Gibson, G.E., Beal, M.F. (2008) Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases. Neuroscience 153:986-996.
Karuppagounder, S. S., Xu, H., Pechman, D., Chen, L. H., Degiorgio, L. A. and Gibson, G. E. (2008) Translocation of Amyloid Precursor Protein C-terminal Fragment(s) to the Nucleus Precedes Neuronal Death due to Thiamine Deficiency-induced Mild Impairment of Oxidative Metabolism. Neurochemical Research, 33, 1365-1372.
Karuppagounder, S.S., Xu, H., Shi, Q., Chen, L.H., Pedrini, S., Pechman, D.P., Baker, H.A., Beal, M.F., Gandy, S.E., Gibson, G.E. 2009. Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiology of Aging 30:1587-1600.
Karuppagounder S.S., Pinto J.T., Xu H., Chen L.H., Beal M.F., Gibson, G.E. 2009. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's Disease. Neurochemistry International 54:111-118.
Shi Q., Risa Ø., Sonnewald U., Gibson G.E. 2009. Mild reduction in the activity of the α-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis. J Neurochem. 54:111-8.
Dumont M, Ho DJ, Calingasan NY, Xu H, Gibson GE, Beal MF. 2009. Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition. Free Radical Biology and Medicine 47:1019-1027.
Yang, L., Shi, Q., Ho, D.J., Starkov, A.A., Wille, E.J., Xu, H., Chen, H.L., Zhang, S. Cliona, M., Stack, C.M., Calingason, N.Y., Gibson, G.E., Beal, M.F. (2009) Mice deficient in dihydrolipoyl succinyltransferase show increased vulnerability to mitochondrial toxins. Neurobiology of Disease 36:320-330.
Area-Gomez, E. , de Groof, J.D., Boldogh, I., Bird, T.D., Gibson, G.E., Koehler, C.M., Duff, K.E., Naini, A., Bonilla, E., Yaffe, M.P., Pon, L.A., Schon, E.A. (2009) Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria. Am J Pathol 175:1810-1816.
Karuppagounder, S. S., Xu, H., Pechman, D., Chen, L. H., Degiorgio, L. A. and Gibson, G. E. (2008) Translocation of Amyloid Precursor Protein C-terminal Fragment(s) to the Nucleus Precedes Neuronal Death due to Thiamine Deficiency-induced Mild Impairment of Oxidative Metabolism. Neurochemical Research, 33, 1365-1372. PMCID:2870991
Karuppagounder, S.S., Xu, H., Shi, Q., Chen, L.H., Pedrini, S., Pechman, D.P., Baker, H.A., Beal, M.F., Gandy, S.E., Gibson, G.E. 2009. Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiology of Aging 30:1587-1600. PMCID 2782730
Karuppagounder S.S., Pinto J.T., Xu H., Chen L.H., Beal M.F., Gibson, G.E. 2009. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's Disease. Neurochemistry International 54:111-118. PMCID 2892907
Shi Q., Risa Ø., Sonnewald U., Gibson G.E. 2009. Mild reduction in the activity of the α-ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis. J Neurochem. 54:111-8. PMCID 2750872
Dumont M, Ho DJ, Calingasan NY, Xu H, Gibson GE, Beal MF. 2009. Mitochondrial dihydrolipoyl succinyltransferase deficiency accelerates amyloid pathology and memory deficit in a transgenic mouse model of amyloid deposition. Free Radical Biology and Medicine 47:1019-1027. PMCID 2761144
Yang, L., Shi, Q., Ho, D.J., Starkov, A.A., Wille, E.J., Xu, H., Chen, H.L., Zhang, S. Cliona, M., Stack, C.M., Calingason, N.Y., Gibson, G.E., Beal, M.F. (2009) Mice deficient in dihydrolipoyl succinyltransferase show increased vulnerability to mitochondrial toxins. Neurobiology of Disease 36:320-330.
Area-Gomez, E. , de Groof, J.D., Boldogh, I., Bird, T.D., Gibson, G.E., Koehler, C.M., Duff, K.E., Naini, A., Bonilla, E., Yaffe, M.P., Pon, L.A., Schon, E.A. (2009) Presenilins Are Enriched in Endoplasmic Reticulum Membranes Associated with Mitochondria. Am J Pathol 175:1810-1816. PMCID 2774047.
Huang HM, Chen HL, Gibson GE (2010) Thiamine and Oxidants Interact to Modify Cellular Calcium Stores. Neurochem Res. 35:2107–2116 PMCID 3085841 http://www.ncbi.nlm.nih.gov/pubmed/20734230
Bubber P, Haroutunian V, Gibson GE, Blass JP. 201. Abnormalities in the tricarboxylic acid (TCA) cycle in brain of schizophrenia patients. European Neuropsychopharmacology 21:254-260. PMCID 3033969
http://www.ncbi.nlm.nih.gov/pubmed/21123035
Nilsen, L.H., Shi Q., Gibson G.E., Sonnewald U., (2011) Brain [U-13C]glucose metabolism in mice with decreased α-ketoglutarate dehydrogenase complex activity J. Neuroscience Research (in press)
Shi Q., Xu H, Yu H, Zhang N, Ye Y, Estevez AG, Deng, H., Gibson G.E. 2011. Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex. J. Biological Chemistry 286: 17640-17648.
Shi, Q. Gibson, G.E. 2011. Up-regulation of the mitochondrial malate dehydrogenase by oxidative stress is mediated by miR-743a J. Neurochem. (in press)
Chapters and reviews
Ke, ZJ and Gibson, GE. 2004. Selective Response of Various Brain Cell Types During Neurodegeneration Induced by Mild Impairment of Oxidative Metabolism. Neurochemical Intl. 45:361-369.
Gibson GE and Huang 2004. Mitochondrial enzymes and endoplasmic reticulum calcium stores as targets of oxidative stress in neurodegenerative diseases. J. Bioenergetics and Biomembranes 36:335-341.
Gibson GE, Blass JP, Beal MF, Bunik V. 2005. The α-Ketoglutarate dehydrogenase complex: a mediator between mitochondria and oxidative stress in neurodegeneration. Molecular Neurobiology 31:1-31.
Gibson GE , Huang HMH 2005. Commentary. Oxidative stress in Alzheimer's Disease. Neurobiology of Aging 26:575-578.
Blass, JP, and Gibson, GE. 2006. Correlations of disability and biologic alterations in Alzheimer Brain and test of significance by a therapeutic trial in humans. Journal of Alzheimer's Disease 9:207–218.
Joseph J.A. and Gibson. GE. 2007. Chapter 4.2. Coupling of neuronal function to oxygen and glucose metabolism through changes in neurotransmitter dynamics as revealed with aging, hypoglycemia and hypoxia. Handbook of Neurochemistry and Molecular Biology. 3rd Edition Volume 5. Brain energetics from genes to metabolites to cells: Integration of molecular and cellular processes. Edited by Gary E. Gibson and Gerald Dienel pp 297-320.
Bunik VI, Schloss JV, Pinto JT, Gibson GE, Cooper AJL. 2007. Enzyme-Catalyzed Side Reactions with Molecular Oxygen May Contribute to Cell Signaling and Neurodegenerative Diseases. Neurochemical Research 32(4-5):871-892.
Gibson, GE, Blass JP. 2007. Thiamine-Dependent Processes and Treatment Strategies in Neurodegenerations. Antioxidants and Redox Signaling. 9 (10) 1-15.
Shi, Q. and Gibson, G.E. 2007. Oxidative Stress and Transcriptional Regulation in Alzheimer's Disease. Alzheimer Disease & Associated Disorders - An International Journal. 21(4):276-291.
Karuppagounder, S.S. and Gibson, G.E. 2008. Thiamine deficiency: a model of metabolic encephalopathy and of selective neuronal vulnerability. In Metabolic Encephalopathy [Ed. David McCandless] Springer Press. (in press).
Gibson G.E., Karuppagounder S.S., Shi Q. 2008. Oxidant Induced Changes in Mitochondria and Calcium Dynamics in the Pathophysiology of Alzheimer's Disease (IN: Mitochondria and Oxidative Stress in Neurodegenerative Disorders. Editors Gibson GE, Ratan, R.R., Beal M.F.) Ann. N.Y. Acad. Sci. 1147: 221–232.
Gibson G.E., Starkov A., Blass J.P., Ratan R.R., Beal M.F. 2010. Cause and Consequence: Mitochondrial Dysfunction Initiates and Propagates Neuronal Dysfunction, Neuronal Death and Behavioral Abnormalities in Age Associated Neurodegenerative Diseases. IN Mitochondrial Dysfunction: Mitochondrial Diseases and Pathways. Special issue Biochimica et Biophysica Acta Molecular Basis of Disease 1802:122–134.
Gibson G.E., Shi Q. 2010. A Mitocentric View of Alzheimer's Disease Suggests Multi-Faceted Treatments. Journal of Alzheimer's Disease
