Research Overview
The Hemophilia Center is currently conducting or participating in over 24 active clinical research protocols. These include industry-sponsored new drug trials, as well as NIH and privately-funded multi-center clinical and epidemioloci studies on which Drs. DiMichele or Acharya are principal investigators. Our center has several approaches to long-term hemophilia care available to our patients who wish to participate. We embrace the opportunity to educate the bleeding disorders community about the latest treatment plans that have proven to be beneficial and allow for a healthy and productive livelihood. Patients that are followed at our treatment center who meet eligibility criteria for research protocols are offered the opportunity to enroll if they choose to do so. 1. An International, Randomized, Controlled Trial of Immune Tolerance Induction 2. CDC Protocol #1671 - Universal Data and Serum Specimen Collection System for Hemophiliacs 3. Comprehensive Care in Patients with Hemophilia 4. Fibrogammin P: Human Plasma Derived FXIII Concentrate in patients with Congenital FXIII Deficiency 5. Genetics of Inhibitor Formation in Hemophilia 6. Second Multi-center Hemophilia Cohort Study 10. The Anonymous Use of Waste Blood Samples for Disease-Related Research 11. The FEIBA NovoSeven Comparative Study (The FENOC Study) 12. Sonography with Power Doppler in Hemophilic Synovitis 13. Angiogenesis and Hemophilic Synovitis 14. The Perceptions and Acceptability of Gene Transfer for Technology Among Parents of Children with Hemophilia: A Pilot Study 15. Recombinant Antihemophilic Factor (rAH-PFM) Manufactured and Formulated Without Added Human or Animal Proteins: Evaluation of Immunogenicity Efficacy and Safety in Previously Untreated Patients with Hemophilia A 16. Investigative Molecular Diagnosis of Individuals with Congenital Disorders of Hemostasis 17. Hemophilia Inhibitor Genetics Study 18. Age at First Infusion Study 19. A Prospective Randomized Pilot Study on the Effect of Patient Counseling on Adolescent Hemophilia Patient Compliance with Bleeding Logs 20. Epidemiology and Treatment of Circulating Anticoagulants in Patients with Hemophilia and vWd HTRS Registry 21. Validations of A Global Assay of Coagulation and Fibrinolysis in Children with Disorders of Thrombosis and Hemostasis 22. Females with Severe or Moderate Hemophilia A or B: A Multi-center Study 23. Study of the Safety and Efficacy of Antihemophilic Factor vWf Complex (Humate P) Using Individualized Dosing in Pediatric and Adult Surgical Patients with vWd 24. A Multicenter Study to Describe the Immunogenic Epitope(s) of factor VIII in Previously Treated Patients with Congenital Hemophilia A Who Develop de Novo factor VIII Inhibitors While Receiving Factor VIII Infusion Therapy
