Researcher's Home Page
 
  Biography
 
Publications
 
  Honors and Awards
 
 
Appointments
 
Associate Professor of Cell and Developmental Biology
Associate Professor of Pediatrics
Stavros S. Niarchos Associate Professor in Pediatric Cardiology
 
Weill Cornell \r\nPhysician
   

Lyden, David C.
 (212) 746-3941  (212) 746-8423

Peer Reviewed Articles

  1. Lyden DC, Huber SA. Aggravation of Coxsackie?s virus, group B typed 3 induced myocarditis antigens in pregnant balb/c mice and animals treated with progesterone. Cellular Immunology 1984; 82: 462-472.

  2. Lyden DC, Olszewski J, Huber S. Influence of sex hormones on Coxsackie?s virus group B type 3 induced myocarditis in balb/c mice. European Heart Journal 1986; 7: 1-3.

  3. Lyden DC, Olszewski J, Feran M, Job LP, Huber SA. Coxsackie virus B3-induced myocarditis; effect of sex steroids on viremia and infectivity of cardiocytes. Am J Pathology 1987; 126: 432-438.

  4. Lyden DC, Olszewski J, Huber S. Variation in susceptibility of balb/c mice to Coxsackie?s virus group B type 3 myocarditis with age. Cellular Immunology 1987; 105: 1-8.

  5. Huber SA, Lyden DC, Lodge PA. Immunopathogenesis of experimental Coxsackie?s virus induced myocarditis ? role of autoimmunity. HERZ (German Heart Journal) 1985; 10: 1-7.

  6. Huber SA, Lyden DC, Lodge PA. Cardiac injury in experimental Coxsackie?s virus induced myocarditis ? results from autoimmunity of cardiocyte antigens. Pediatric Cardiology 1985; 2: 964-966.

  7. Job LP, Lyden DC, Huber SA. Demonstration of suppressor cells in Coxsackie?s virus group B type 3 female balb/c mice, which prevent myocarditis. Cellular Immunology 1986; 98: 104-113.

  8. Lyden DC, Mason WP, Finlay JL. The expanding role of chemotherapy for pediatric supratentorial malignant gliomas. J Neurooncology 1996; 28: 185-191.

  9. Mason WP, Grovas A, Halpern S, Dunkel IJ, Garvin J, Heller G, Rosenblum M, Gardner S, Lyden DC, Sands SS, Pucetti D, Lindsey K, Merchant TE, O?Malley B, Bayer L, Petriccione MM, Allen J, Finlay JL. Intensive chemotherapy and bone marrow reconstitution for young children with newly diagnosed malignant brain tumors. J Clinical Oncology 1998; 16(1): 210-221.

  10. Lyden D, Young AZ, Zagzag D, Yan W, Gerald W, O?Reilly R, Bader BL, Hynes RO, Zhuang Y, Manova K, Benezra R. Id1 and Id3 are required for neurogenesis, angiogenesis, and vascularization of tumour xenografts. Nature (article), (News and Views) 1999; 401: 670-677.

  11. Hattori K, Dias S, Heissig B, Hackett NR, Lyden D, Tateno M, Hicklin DJ, Zhu Z, Witte L, Crystal RG, Moore MAS, Rafii S. Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. J Exp Med 2001; 193: 1005-1014.

  12. Lyden D, Hattori K, Dias S, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Hackett NR, Crystal RG, Moore MAS, Hajjar KA, Manova K, Benezra R, Rafii R. Impaired recruitment of marrow-derived VEGRF1+ hematopoietic and VEGRF2+ endothelial precursor cells block tumor angiogenesis and growth. Nature Medicine (article) 2001; 7(11): 1194-1201.

  13. Lyden D, et. al. Bone marrow feeds hungry tumors. Science-now 2001; (1106): 2.Lyden D, et. al. Herding vascular precursors. Nature Reviews-Cancer 2001; (1): 91.

  14. Benezra R, Rafii S, and Lyden D. The Id proteins and angiogenesis. Oncogene 2001; (20):8334-8341.Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett, NR, Besmer P, Crystal RG, Lyden D, Moore MAS, Werb Z, Rafii S. Recruitment of stem cells from bone marrow niche requires MMP-9 mediated release of Kit-ligand. Cell 2002; 109: 625-637.

  15. Rafii S, Meevs S, Dias S, Hattori K, Heissig B, Schmelkov S, Rafii D, Besmer, P, Lyden D. Contribution of marrow-derived progenitors to vascular and cardiac regeneration. Seminars in Cell and Developmental Biology. 2002; 13: 61-67.

  16. Edelberg J, Tang L, Hattori K, Lyden D, Rafii S. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenesis function. Circulation Research 2002; 90: E89-E93.

  17. Hattori K, Heissig B, Dias S, Ferris B, Hackett NR, Hicklin DJ, Wu Y, Zhu Z, Bohlen P, Witte L, Hendriks PJ, Crystal RG, Moore MAS, Werb Z, Lyden D, Rafii S. Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment. Nature Medicine (article) 2002; 8: 841-9.

  18. Rafii S, Lyden D, Benezra R, Hattori K, Heissig B. Vascular and hematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nature Reviews?Cancer 2002; 2 (11): 826-35.

  19. Benezra R, De Candia P, Li H, Romero E, Lyden D, Rafii S, Ruzinova M. A genetic approach to understanding tumor angiogenesis. Cold Spring Harb Symp Quant. Biol. 2002; 67: 249.54.

  20. Garcia-Barros M, Paris F, Cordon-Cardo C, Lyden D, Rafii S, Haimovitz-Friedman A, Fuk Z, Kolesnick R. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 2003; 300 (5622): 1155-9.

  21. Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nature Medicine 2003; 9 (6): 702-712.

  22. Begemann M, Lyden D, Rosenblum MK, Lis e, Wolden S, Antunes NL, Dunkel IJ. Primary leptomeningeal primitive neuroectodermal tumor. J Neurooncol. 2003; 63: 299-303.

  23. Wolden SL, Dunkel IJ, Souweidane MM, Happersett L, Khakoo Y, Schupak K, Lyden D, Leibel SA. Patterns of failure using a conformal radiation therapy tumor bed boost for medulloblastoma. J Clin Oncol. 2003 21(16): 3079-83.

  24. Avecilla ST, Hattori K, Heissig B, Tejada R, Liao F, Shido K, Jin DK, Dias S, Zhang F, Hartman TE, Hackett NR, Crystal RG, Witte L, Hicklin DJ, Bohlen P, Eaton D, Lyden D, De Sauvage F, Rafii R. Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nature Medicine (article) 2004 10 (1): 64-71.

  25. Vidal A, Zacharoulis S, Guo W, Shaffer D, Giancotti F, Bramley A, De la Hoz Torres C, Jensen K, Kato D, MacDonald D, Knowles J, Yeh N, Frohman LA, Rafii S, Lyden D (corresponding author), Koff A. p130Rb2 and p27kip1 cooperate to control mobilization of angiogenic progenitors from the bone marrow. PNAS. 2005 102 (19): 6890.

  26. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature (article) (News and Views p.750). 2005 438 (7069): 820-827.

  27. Kaplan RN, Lyden D. Sending the advance party for metastases. Journal of Cell Biology 2006 172 (1): 4.

  28. Kaplan RN, Lyden D. Metastases: setting up shop. Nature Reviews Cancer 2006 6 (1): 3.

  29. Kaplan RN, Lyden D. Envoys of metastasis. Nature Medicine 2006 12 (1): 18.Jin DK, Kopp H, Petit I, Shido K, Young LM, Kanhai G, Amano H, Acevilla S, Heissig B, Hattori K, Zhang F, Hicklin DJ, Dunn A, Salari H, Werb Z, Hackett NR, Crystal RG, Lyden D, Rafii S. Cytokine-mediated Deployment of SDF-1 revascularization through recruitment of CXCR4+ hemangiocytes. Nature Medicine 2006 12 (5):557-567.

  30. Karajannis MA, Lyden DC, Khakoo Y, Dunkel IJ. Treatment-related Myelodysplastic Syndrome After Chemotherapy for Childhood Low-grade Astrocytoma. J Pediatric Hematol Oncol. 2006 28 (10):700.

  31. Rafii S. and Lyden D. S100 chemokines mediate bookmarking of pre-metastatic niches. Nature Cell Biology. 2006 8:1321-1323.

  32. Gilheeney SW, Lyden DC, Sgouros S, Antunes N, Gerald W, Kramer K, Lis E, Meyers P, Rosen N, Thaler HT, Trippett T, Wexler L, Dunkel IJ. A phase II trial of thalidomide and cyclophosphamide in patients with recurrent or refractory pediatric malignancies. Pediatr Blood Cancer 2007 49(3):261-265.

  33. Dunkel IJ, Lee TC, Shi W, Beaverson KL, Novetsky D, Lyden D, Finlay JL, McCormick B, Abramson DH. A phase II trial of carboplatin for intraocular retinoblastoma. Pediatr Blood Cancer. 2007 49(5):643-648.

  34. Rafii S and Lyden D. Cancer; A few to flip the angiogenic switch. Science 2008 319:163-164.

  35. Cross KJ, Bomsztyk BS, Weinstein AL, Spector JA, Lyden D. A novel method for targeted gene therapy in ischemic tissues via viral transfection of an expression cassette containing multiple repeats of hypoxia response element (HRE). Plastic and Reconstructive Surgery. In Press.

  36. Shmelkov SV, Butler J, Hooper AT, Hormigo A, Kushner J, Milde T, St. Clair R, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, Lyden D (corresponding author), Rafii S. ?CD133 identifies luminal differentiated epithelium and both CD133+ and CD133- cells initiate metastatic epithelial carcinomas. Journal of Clinical Investigation, Under 2nd Revision

  37. Rafii, S., Heissig, B., Shido, K., Tejada, R., Coshima, M., Friedrich, M., Hicklin, D., Zhu, Z., Witte, L., Bohlen, P., Kerris, B., Eaton, D., De Sauvage, F., Hattori, K., Lyden, D.: Thrombopoitin-mediated angiogenesis and thrombopoiesis promotes vascular stability and growth. (Submitted to Nature).

  38. Vidal, A., Zacharoulis, S., Guo, W., Giancotti, F., Shaffer, D., De la Hoz Torres, C., Kato, D., Knowles, J., Yeh, N., Frohman, L.A., Lyden, D. (corresponding author), Koff, A.: p27kip1 and p130Rb2 regulate induction, proliferation and mobilization of angiogenic cells in the bone marrow. (under review-Cell).

  39. Heissig, B., Hattori, K., Liao, F., Shido, K., Tejada, R., Hockett, N.R., Crystal, R.G., Eaton, D., Bohlen, P., Lyden, D., De Sauvage, F., Rafii, R.: Chemokine-mediated localization of hematopoietic progenitors to the marrow vascular niche is required for platelet production. (Under revision, Science).

  40. Podolanczuk A, Kaplan RN, Psaila B, Rafii S, Lyden D. ?Targeting the Steps in Metastatic Progression? in Bone and Cancer. (In Press, February 2008).


Peer-Reviewed Books, Book Chapters and Reviews

  1. Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Am.J Opthalmol. 2003 136:1198.

  2. Benezra R., Rafii S., Lyden D. ?Modeling Blood Vessel Formation in the Mouse? in Mouse Models of Cancer. Wiley-Liss Press. 2005 Chapter 17.Shmelkov SV, St. Clair R, Lyden D, Rafii S. ?AC133/CD133/Prominin-1? International Journal of Biochemistry and Cell Biology. 2005 37(4):715-719.

  3. Rafii S, Lyden D, Jin D, Hopper A. ?Contribution of Pro-Angiogenic Hematopoietic Cells to Vascularization of Tumor and Ischemic Tissue? in Angiogenesis: From Basic Science to Clinical Applications. Taylor & Francis Press. 2006

  4. Kaplan R, Rafii S, Lyden D. ?The Pre-Metastatic Niche: Preparing the Soil?, Cancer Research. 2006 66(23):11089-11093.

  5. Kaplan RN, Psaila B, and Lyden D. ?Bone marrow cells in the Pre-Metastatic Niche within Bone and Beyond?. Cancer Metastasis Rev. 2006 25(4):521-529.

  6. Kaplan R, Psaila B, Lyden D. ?Niche-to-niche migration of bone marrow-derived cells?. Trends Mol Med. 2007 13(2):72-81.

  7. Psaila B, Kaplan RN, and Lyden D. ?Priming the Soil for Breast Cancer Metastasis: The Pre-Metastatic Niche?. Breast Disease. 2007 .26:65-74.

  8. Podolanczuk A, Kaplan RN, Psaila B, Rafii S, Lyden D. ?Targeting the Steps in Metastatic Progression? in Bone and Cancer. (In Press, February 2008).Rafii DC, Butler J, Psaila B, Jin DK, Hooper AT. Lyden D. ?Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells. Atherosclerosis Thrombosis and Vascular Biology. 2008 28(2):217-222.

  9. Wels J, Kaplan R, and Lyden D. ?Migratory Neighbors and Distant Invaders: Tumor-associated Niche Cells?. Genes and Development. 2008 22(5):559-574.

  10. Papaspyridonos M. and Lyden D. ?In Vivo Models of Angiogenesis? in Methods in Enzymology.Dan Welch and David Lyden, Co-Editors, ?Cancer Metastasis: Biologic Basis and Therapeutics? Cambridge University Press (Publication, December 2008).
   
   
 
Education
Ph.D., University of Vermont, 1985
M.D., Brown University School of Medicine, 1989
 
Top Back to Top
© Weill Cornell Medical College
Cornell University (Ithaca) | Privacy Notice | Disclaimer