Publications
Fuse, N., Maiti, T., Wang, B., Porter, J.A., Tanaka Hall, T.M., Leahy, D.J., and Beachy, P.A. (1999). Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched. Proc. Natl. Acad. Sci. U S A. 96:10992-10999.
Chen, C.H., von Kessler, D.P., Park, W., Wang, B., Ma, Y., Beachy, P. A. (1999). Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 98:305-316.
Wang, B., Fallon, J.F., Beachy, P.A. (2000). Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell100:423-434.
Taipale, J., Chen, J.K., Cooper, M.K., Wang, B., Mann, R.K., Mlenkovic, L.,Scott, M.P.,Beachy, P.A. (2000) Effects of oncogenic mutations in Smootherned and Patched can be reversed by cyclopamine. Nature 406:1005-1009.
Watkins, D. N., Berman, D. M., Burkholder, S. G., Wang, B,, Beachy, P. A. & Baylin, S. B. (2003) Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature 422: 313-316.
Lum, L., Zhang, C., Oh, S., Mann, R.K., von Kessler, D.P., Taipale, J., Weis-Garcia, F., Gong, R., Wang, B., Beachy, P.A. (2003). Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol. Cell 12:1261-74.
Bastida, M.F., Delgado, M.D., Wang, B., Fallon, J.F., Fernandez-Teran, M., Ros, M.A. (2004). Levels of Gli3 repressor correlate with BMP4 expression and apoptosis during limb development. Dev. Dyn. 231:148-160.
Liu A., Wang, B., Niswander, L.A. (2005) Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors. Development 132:3103-11.
May, S.R., Ashique, A.M., Karlen, M., Wang, B., Shen, Y., Zarbalis, K., Reiter, J., Ericson, J., Peterson, A.S. (2005). Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli. Dev. Biol. 287:378-89.
Wang, B. and Li, Y. (2006). Evidence for the direct involvement of bTrCP in Gli3 protein processing. Proc. Natl. Acad. Sci. U S A. 103:33-8.
Pan, P., Bai, C. B., Joyner, A. L., Wang, B. (2006). Sonic Hedgehog Signaling Regulates Gli2 Transcriptional Activity by Suppressing its Processing and Degradation. Mol. Cell. Biol. 26:3365-77.
Pan, P. and Wang, B. (2007). A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome. J. Biol. Chem.282:10846-10852.
Wang, C., Pan, Y., and Wang, B. (2007). A hypermorphic mouse Gli3 allele results in a polydactylous limb phenotype. Dev. Dyn. 236:769-776.
Wang, C., Rüther, U., and Wang B. (2007). The Shh-independent activator function of the full-length Gli3 protein and its role in vertebrate limb digit patterning. Dev. Biol. 305:460-469.
Vierkotten, J., Dildrop, R., Peters, T., Wang, B., and Ruether, U. (2007) Ftm is a novel basal body protein of cilia involved in Shh signaling. Development 134:2569-2577.
Hill, P., Wang, B., and Rüther, U. (2007).The molecular basis of Pallister-Hall associated polydactyly. Human Mol. Genet. 16:2089-96.
Li, N., Singh, S., Cherukuri, P., Li, H., Yuan, Z., Ellisen, L.W., Wang, B., Robbins, D., Direnzo, J. (2008). Reciprocal Intra-Epithelial Interactions between TP63 and Hedgehog Signaling Regulate Quiescence and Activation of Progenitor Elaboration by Mammary Stem Cells. Stem Cells. 26:1253-1264.
Breunig, J.J., Sarkisian, M.R., Arellano, J.I., Morozov, Y. M., Ayoub, A. E., Sojitra, S., Wang, B., Flavell, R. A., Rakic, P. and Town, T. (2008). Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling. Proc. Natl. Acad. Sci. USA. 105(35): 13127–13132.
Low, W-C*., Wang, C*, Pan, Y*., Huang, X-Y, Chen, J.K., Wang, B. (2008). The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning. Dev. Biol. 321:188-96. (*, the first authors).
Cortellino, S., Wang, C., Wang, B., Bassi, M.R., Caretti, E., Champeval, D., Calmont, A., Jarnik, J., Burch, J., Zaret, K., Larue, L., and Bellacosa, A. (2009). Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4. Dev. Biol. 325:225-237.
Pan,Y., Wang, C., and Wang, B. (2009).Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development. Dev. Biol. 326:177-189.
Zhao, M., Ko, S.Y., Liu, J.H., Chen, D., Zhang, J., Wang, B., Harris, S.E., Oyajobi, B.O., Mundy, G.R. (2009).Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2. Mol. Cell. Biol. 29(5):1291-305.
Fei, D.L., Li, H., Kozul, C.D., Black, K.E., Singh, S., Gosse, J.A., DiRenzo, J., Martin, K.A., Wang, B., Hamilton, J.W., Karagas, M.R., and Robbins, D.J. (2010). Activation of Hedgehog signaling by the environmental toxicant arsenic. Cancer Res. 70(5):1981-8. PMID: 20179202.
Wang, C., Pan, P., and Wang, B. (2010). Suppressor of fused and SPOP regulate the stability, processing, and function of Gli2 and Gli3 full-length activators but not their repressors. Development. 137:2001-2009.
