SELECTED PUBLICATIONS

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• Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell. 2008 May;14(5):661-73.
  PMID: 18477450

• Sauve AA.  NAD+ and vitamin B3: from metabolism to therapies. J Pharmacol Exp Ther. 2008 Mar;324(3):883-93. Epub 2007 Dec 28. Review.
  PMID: 18165311

• Yang T, Chan NY, Sauve AA.  Syntheses of nicotinamide riboside and derivatives: effective agents for increasing nicotinamide adenine dinucleotide concentrations in mammalian cells. J Med Chem. 2007 Dec 27;50(26):6458-61. Epub 2007 Dec 6.
  PMID: 18052316

• Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C.   Nicotinamide riboside kinase structures reveal new pathways to NAD+. PLoS Biol. 2007 Oct 2;5(10):e263.
  PMID: 17914902

• Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA.  Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell. 2007 Sep 21;130(6):1095-107.
  PMID: 17889652

• Fu M, Liu M, Sauve AA, Jiao X, Zhang X, Wu X, Powell MJ, Yang T, Gu W, Avantaggiati ML, Pattabiraman N, Pestell TG, Wang F, Quong AA, Wang C, Pestell RG. Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol. 2006 Nov;26(21):8122-35. Epub 2006 Aug 21.
  PMID: 16923962

• Yang T, Sauve AA. NAD metabolism and sirtuins: Metabolic regulation of protein deacetylation in stress and toxicity. AAPS J. 2006 Oct 6;8(4):E632-43. Review.
  PMID: 17233528

   

• Qin W, Yang T, Ho L, Zhao J, Chen L, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimers disease amyloid neuropathology by calorie restriction. J Biol Chem. 2006 Aug 4;281(31):21745-54. Epub 2006 Jun 2.
  PMID: 16751189

• Sauve AA, Wolberger C, Schramm VL, Boeke J. The Biochemsitry of Sirtuins. Annu Rev Biochem. 2006;75:435-65. Review.
  PMID: 16756498

• Yang T, Fu M, Pestell R, Sauve AA. SIRT1 and Endocrine Signaling. Trends Endocrinol Metab. 2006 Jul;17(5):186-91. Epub 2006 May 8. Review.
  PMID: 16684606

• Sauve AA, Moir RD, Schramm VL, Willis IM. Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Mol Cell., 2005, 17(4):595-601.

PMID: 15721262

• Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, Hay RT, Gu W, Pestell RG. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell-cycle regulatory domain 1. J. Biol. Chem. 2005, 280(11):10264-76.

PMID: 15632193

 

• Sauve AA, Schramm VL. Sir2: The biochemical mechanism of NAD+-dependent protein deacetylation and ADP-ribosyl enzyme intermediates. Curr. Med. Chem. 2004, 11:807-826.

• Sauve AA, Schramm VL. Sir2 regulation by nicotinamde results from switching between base exchange and deacetylation chemistry. Biochemistry 2003, 42(31):9249-9256.

• Sauve AA, Schramm VL. Mechanism-based inhibitors of CD38: A mammalian ADP-ribosylcyclase. Biochemistry 2002, 41:8455-8463.

• Sauve AA, Celic I, Avalos J, Deng HT, Boeke J, Schramm VL. Chemistry of gene silencing: The mechanism of NAD+-dependent deacetylation reactions. Biochemistry 2001, 40(51); 15456-15463.

• Sauve AA, Deng HT, Angelletti R, Schramm VL. A covalent intermediate in CD38 is responsible for ADP-ribosylation reactions. J. Amer. Chem. Soc. 2000, 122:7855-7859.

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