Weill Medical College of Cornell University
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Keck Program in Cellular and Molecular
Biophysics of Signal Transduction

Weill Cornell Medical College - New York City

The Keck program is a new research and training program between Cornell University’s Ithaca and Weill Medical College in New York City campuses.  The objective of this program is to develop a detailed understanding of the complex molecular processes that regulate cell behavior.  This major scientific challenge requires a coordinated effort of scientists ranging from mathematicians and physicists to cell biologists and physiologists.  The Keck program builds on the University's considerable strengths in these disciplines by synergistically linking teams of researchers at the two campuses.  The program includes joint research projects, shared training of graduate students and postdoctoral fellows, development of inter-campus courses, and installation of equipment to facilitate application of new techniques to key biomedical research problems.

Cornell University - Ithaca, New York

The complete sequencing of the human genome is a landmark achievement in biomedical sciences.  However, a greater challenge now lies before us: understanding how the thousands of different proteins are organized and regulated within cells, tissues and whole organisms.  The scope of this is one that will require decades of work by teams of scientists around the world.  For that reason training of the next generation of scientists is an essential component of the attack on this problem.  Furthermore, the scope of the problem transcends traditional barriers between scientific disciplines, and it will be necessary to train scientists who are knowledgeable in a range of scientific areas, and to establish teams of researchers who work together closely.

The faculty of the Keck Program in Cellular and Molecular Biophysics of Signal Transduction form an exceptionally strong team of researchers with the commitment and expertise to attack this problem in a coordinated effort (see table for links to the web pages of the Keck faculty).  In particular, Cornell has a group of scientists who work at the interface between cell biology and biophysics, and this core group can integrate the efforts of the more physical or biological scientists.  This core of faculty with broad, overlapping interests is one of the distinguishing features of the Keck program.  Reflecting the broad interests of the faculty, the graduate students and postdoctoral fellows in these laboratories come with a breadth of training that enhances a rich, interactive environment.    

The program supports both graduate students and postdoctoral fellows. Graduate students will be admitted into existing Ph.D. programs at both campuses.  Students in the Keck Program will have members of their Committee from both campuses, and interdisciplinary, collaborative training will be a key element of the selection process.  Postdoctoral fellows will be selected for the program based on their prior record and their plans for interdisciplinary training.  In most cases, two mentors will jointly sponsor fellows. Inter-campus graduate courses and special topic seminars for students and postdoctoral fellows will be developed.  These will take advantage of the facilities and expertise in Cornell’s Office of Distance Learning, which already offers several courses simultaneously in New York and Ithaca.

For more information on research opportunities in the Keck program please contact individual faculty members or the directors of the program, F.R. Maxfield (Weill Medical College, NYC), frmaxfie@med.cornell.edu or B. Baird (Ithaca Campus), bab13@cornell.edu.

Faculty
and Research Interests

Weill Medical College

Fred Maxfield, Ph.D.
Membrane traffic and cell motility
(Co-Director)

Olaf S. Andersen, M.D.
Molecular physiology of ion channels

Xin-Yun Huang, Ph.D.
Role of tyrosine kinases in G-protein signaling

Tim McGraw, Ph.D.
Endocytic membrane trafficking

Diana Murry, Ph.D.
Computational analysis of subcellular targeting

Benoit Roux, Ph.D.
Computational studies of ion channels

Tim Ryan, Ph.D.
Biophysical and molecular dissection of synaptic machinery

Hao Wu, Ph.D.
Structural studies of intracellular signaling

Ithaca Campus

Barbara Baird, Ph.D.
Structure and molecular mechanisms of cell membrane receptor proteins.
(Co-Director)

Richard Cerione, Ph.D.
Molecular mechanisms of signal transduction.

Gerald Feigenson, Ph.D.
Physical and chemical properties of biomembranes.

Jack Freed, Ph.D.
Applications of ESR to chemical physics and biophysics.

Manfred Lindau, Ph.D.
Mechanisms of exocytosis and endocytosis.

Watt W. Webb, Sc.D.
Dynamics of basic biophysical processes.