Lymphoma and Multiple Myeloma

Patients must have histologically documented classical Hodgkin lymphoma. No prior treatment (chemotherapy or radiation therapy) for Hodgkin lymphoma. Patients must have at least one hypermetabolic lesion identifiable on initial PET scan.

Patients will be treated with ABVD (Adriamycin 25 mg/m2, bleomycin 10 units/m2, vinblastine 6 mg/m2 and dacarbazine 375 mg/m2) on Days 1 and 15 of each cycle
according to standard treatment guidelines.

Treatment cycles will be repeated every 28 days. Patients whose PET scans are negative after one cycle of treatment will receive two more cycles (total 3 cycles) of chemotherapy. Patients whose PET scans are positive
after one cycle of treatment will go off study and continue therapy as per their primary treating physician. Patients continuing on study will be evaluated for response after Cycle 1 and after completion of treatment.