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New York Infant Asylum was chartered in 1865 and opened its doors at 106th Street primarily to provide care for foundlings and abandoned children. By 1871, when it moved to 24 Clinton Place, its function had expanded to include a lying-in department and child-care training for mothers. By 1873, most of the asylum was moved to new quarters on 61st Street and Amsterdam Avenue, leaving only a House of Reception downtown, which closed in 1879. The first country branch of the asylum opened in Flushing in 1872 and existed until 1881, with a second opening in Mount Vernon in 1878.
The intended objects of the charity of the asylum were unwanted children, and its purpose was to find them homes and provide a wholesome atmosphere until their placement. As an incident to this purpose, obstetrical care was provided for unwed or indigent women. However, the charity of the asylum was not wholly without restrictions. An unwed mother could receive care during her first pregnancy only, and not for any subsequent pregnancies. The theory of Board of Managers was that it was human to make one mistake, but immoral to make two.
In 1899, New York Asylum for Lying-In Women was absorbed into the lying-in department of New York Infant Asylum. In 1910, New York Infant Asylum and Nursery and Child's Hospital consolidated to form New York Nursery and Child's Hospital, which became part of New York-Hospital-Cornell Medical Center in 1934. That center is today known as NewYork-Presbyterian Hospital/Weill Cornell Medical Center.

